光生物调节在重症肺部感染辅助治疗中的研究进展

Advances in photobiomodulation as adjunctive therapy in severe pulmonary infections

肺部感染是临床最常见的感染性疾病之一,其发病率和病死率逐年上升,重症肺部感染,尤其是COVID-19,给社会和家庭带来巨大的负担。因此,我们迫切需要研究和开发可用于控制肺部感染发生发展的有效抗菌抗炎策略。光生物调节(PBM)治疗主要是通过细胞内的光化学反应影响细胞代谢途径和基因表达模式,具有抗菌杀菌、消除炎症、调节免疫、促进血液循环和组织修复等作用,逐渐成为医学领域的新型治疗手段。本综述以PBM治疗的细胞和分子机制为切入点,深入探讨PBM辅助治疗肺部感染的可行性,以期为临床重症肺部感染患者寻求新的治疗策略,改善患者预后。

Pulmonary infection is one of the commonest infectious diseases in clinical practice.Its incidence and mortality rates increase year by year.Severe pneumonia,especially COVID-19,places a significant burden on societies and families.There is,therefore,an urgent need to develop more effective antimicrobial and anti-inflammatory strategies to control severe pulmonary infections.PBM,with intracellular photochemical reactions affecting cellular metabolic pathways and gene expression patterns,is a novel therapeutic tool in medicine.It has antibacterial and bactericidal effects,eliminate inflammation,regulate immunity,and promote blood circulation and tissue repair.This review focuses on the cellular and molecular mechanisms of PBM to explore the feasibility of PBM as adjuvant therapy for pulmonary infection and find new treatment strategies for patients with severe pneumonia and improve their prognosis.