蜈蚣败毒饮联合火针治疗斑块型银屑病(血瘀证)的疗效及对血液流变学的影响

Clinical Observation on Efficacy of Wugong Baidu Yin(蜈蚣败毒饮) Combined with Fire Needle in the Treatment of Plaque Psoriasis(Blood Stasis Syndrome)and Its Influence on Hemorheology

目的探讨蜈蚣败毒饮联合火针治疗斑块型银屑病(血瘀证)的临床疗效及对血液流变学的影响。方法从黑龙江中医药大学附属第一医院2018年12月—2020年7月诊治的斑块型银屑病患者辨证属血瘀证者中选取70例,随机分为观察组和对照组,观察组予以口服蜈蚣败毒饮联合火针治疗,对照组仅用火针治疗,最终去除脱落病例,观察组完成33例,对照组完成31例。对两组患者分别于治疗前、治疗第4周、治疗第8周采用银屑病皮损面积及严重程度指数(psoriasis area and severity index,PASI)评分和皮肤病生活质量指数(dermatology life quality index,DLQI)评分记录,以比较两组患者临床疗效和生活质量改善情况,并且检测治疗前后两组患者部分血液流变学相关指标水平。结果治疗第4周和第8周观察组的PASI评分和DLQI评分均低于对照组(P<0.05);观察组有效率和显效率分别达到87.88%和51.52%,临床疗效优于对照组(P<0.05);治疗后两组患者全血黏度低切、血浆黏度、血细胞比容水平较治疗前均降低(P<0.05),且治疗第8周观察组各项指标水平均低于对照组(P<0.05);两组患者在治疗过程中肝功能、肾功能、血细胞分析、尿液分析、标测心电图检查均未发现明显异常。结论蜈蚣败毒饮联合火针治疗斑块型银屑病(血瘀证)疗效可靠、安全性佳,可能与其对患者血液流变学的影响有关。

Objective To investigate the clinical efficacy of Wugong Baidu Yin(蜈蚣败毒饮)combined with fire needle in the treatment of plaque psoriasis(blood stasis syndrome)and its influence on hemorheology.Methods 70 cases of patients with plaque psoriasis diagnosed and treated in first affiliated hospital of heilongjiang university of Chinese medicine from December 2018 to July 2020 with blood stasis syndrome were randomly divided into observation group and control group.The observation group was given oral Wugong Baidu Yin combined with fire needle treatment,the control group only used fire needle treatment,and finally removed the falling cases,the observation group completed 33 cases and the control group completed 31 cases.The two groups of patients were recorded with PASI score and DLQI score before treatment,4th week and 8th week respectively to compare the clinical efficacy and the improvement of quality of life,and detect the level of some hemorheology-related indexes of the two groups of patients before and after treatment.Results The PASI and DLQI scores of the observation group in the 4th and 8th weeks of treatment were lower than those of the control group(P<0.05);the effective rate and significant rate of the observation group reached 87.88%and 51.52%,respectively,and the clinical efficacy was better than the control group(P<0.05);after treatment,the whole blood viscosity,plasma viscosity,and hematocrit levels of the two groups of patients were lower than before treatment(P<0.05),at the 8th week after treatment,the levels of various indicators in the observation group were lower than those in the control group(P<0.05);the two groups of patients had no obvious abnormalities in liver function,kidney function,blood cell analysis,urinalysis,and mapping ECG during the treatment.Conclusion Wugong Baidu Yin combined with fire needle has a reliable curative effect and good safety in the treatment of plaque psoriasis(blood stasis syndrome),which may be related to the effect on the patients’hemorheology.