扶正解毒化痰祛瘀方对肝癌介入术后肝脏微循环及肝纤维化指标影响

Effect of Fuzheng Jiedu Huatan Quyu Decoction(扶正解毒化痰祛瘀方) on Liver Microcirculation and Liver Fibrosis after Interventional Treatment for Liver Cancer

目的探讨扶正解毒化痰祛瘀方对肝癌介入术后肝脏微循环及肝纤维化指标的影响。方法选择2015年1月—2020年12月收治的肝癌患者110例,按随机数表法分为对照组55例和观察组55例,对照组给予肝癌介入治疗,在此基础上,观察组给予扶正解毒化痰祛瘀方治疗,两组均治疗2个周期后,对比两组疗效、中医证候评分、肝脏微循环、肝纤维化指标及健康状况与生活质量[生活质量量表(SF-36)]。结果观察组治疗总有效率78.57%高于对照组57.14%,差异有统计学意义(P<0.05);治疗后,两组黄疸加深、高热烦渴、神昏谵语评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,观察组袢周状态、管袢状态分及流态分均低于对照组,差异有统计学意义(P<0.05);治疗后,两组HA、PC-Ⅲ、C-Ⅳ、LN指标均降低,且观察组HA、PC-Ⅲ、C-Ⅳ和LN水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组健康状况均好转,观察组KPS评分高于对照组,差异有统计学意义(P<0.05);治疗后,两组生理功能、心理功能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论给予肝癌介入术后患者扶正解毒化瘀祛痰方有助于改善肝循环,抑制肝纤维化,提高患者健康状况与生活质量。

Objective To explore the effects of Fuzheng Jiedu Huatan Quyu Decoction(扶正解毒化痰祛瘀方)on liver microcirculation and liver fibrosis after interventional treatment for liver cancer.Methods Selected 110 liver cancer patients admitted to our hospital from January 2015 to December 2020,and divided them into control group of 55 cases and observation group of 55 cases according to the random number table.The control group was given interventional therapy for liver cancer.On this basis,the observation group was given after treatment with Fuzheng Jiedu Huatan Quyu Decoction,the two groups were treated for 2 cycles.The efficacy,TCM syndrome score,liver microcirculation,liver fibrosis index,health status and quality of life were compared between the two groups[quality of life scale(SF-36)].Results The total effective rate of treatment in the observation group was 78.57%higher than that in the control group 57.14%,and the difference was statistically significant(P<0.05);after treatment,the scores of deepening jaundice,high fever,polydipsia,and delirium in the two groups were lower than before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05);after treatment,the periloop state,loop state score and fluid state score of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05);After treatment,the two groups of HA,PC-Ⅲ,C-Ⅳ,LN indicators were reduced,and the observation group HA,PC-Ⅲ,C-Ⅳand LN levels were lower than the control group,the difference was statistically significant(P<0.05);After treatment,the health status of the two groups improved.The KPS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);The scores of,social function,emotional function,and mental health were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Fuzheng Jiedu Huatan Quyu Decoction given to patients after interventional liver cancer can help improve liver circulation,inhibit liver fibrosis,and improve the health status and quality of life of patients.