防己本草考证与化学成分、药理作用研究进展

A Textual Study on Fangji(Stephaniae Tetrandrae Radix)and Advance in Its Modern Pharmaceutical Researches

防己药材历史悠久,为经典名方中常用中药,是祛风止痛、利水消肿的良药。长期的历史发展使防己药材资源种类丰富,但由于各地用药习惯有别、产地发生变迁,临床上常见同名异物现象。马兜铃科汉中防己、广防己和防己科木防己、粉防己均作为防己药材使用,因此明确防己药材基原和现代药学研究进展对临床用药安全和疗效保证至关重要。通过查阅历代本草典籍和现代国内外文献,对临床上常见的4种防己药材的名称、基原、产地变迁等方面进行本草考证,对不同防己药材化学成分和药理药效进行比较总结,为防己药材的现代临床应用和药效学机制研究提供参考。

Fangji(Stephaniae Tetrandrae Radix)is commonly used in classic traditional Chinese medicine prescriptions,with a long history for dispelling wind,relieving pain,promoting urination and reducing swelling.The long-term historical development resulted in abundant resources,but because of different drug using habits in different regions and changes in producing areas,there are obvious clinical phenomenons of homonymous foreign bodies.Aristolochiaceae Hanzhong Fangji,Aristolochiaceae Guangfangji,Tetrandrine Mufangji,and Tetrandrae Fenfangji are all used as Fangji(Stephaniae Tetrandrae Radix),so the determination of the basis of Chinese medicinal materials is particularly important for clinical safety and efficacy.By consulting ancient herbal works and modern documents at home and abroad,we mainly reviewed the changes of 4 kinds of Fangji(Stephaniae Tetrandrae Radix)names,botanical origin and producing area,and summarizes the chemical constituents and pharmacological effects through referring to recent documents in this paper,in order to provide a reference of Fangji(Stephaniae Tetrandrae Radix)for modern clinical applications and further research on its pharmacological mechanisms.