益肾柔肝法对正常体质量指数多囊卵巢综合征患者卵巢储备功能、多囊样改变、内分泌指标和子宫微环境影响

Effects of Yishen Rougan Method on Ovarian Reserve Function,Polycystic Changes,Endocrine Indexes and Uterine Microenvironment in Patients with Normal Body Mass Index Polycystic Ovary Syndrome

目的观察益肾柔肝法对正常体质量指数多囊卵巢综合征患者卵巢储备功能、多囊样改变、内分泌指标和子宫微环境的影响。方法选择2019年12月—2020年12月于医院治疗的116例正常体质量指数多囊卵巢综合征患者为研究对象,按随机数字表法将患者分组,58例患者为研究组,58例患者为对照组,对照组给予屈螺酮炔雌醇片治疗,研究组在对照组基础上联合自拟补肾柔肝汤治疗,两组患者均连续治疗3个月,治疗前、后检测两组患者抑制素B(INHB)、抗苗勒管激素(AMH)、雌二醇(E_(2))、促卵泡刺激素(FSH)、促黄体生成素(LH)、卵泡刺激素(T)、一氧化氮(NO)、内皮素(ET-1)、胆固醇(TC)、甘油三酯(TG)、餐后2 h血糖(2 h PG)、空腹血糖(FPG)水平,采用盆腔B超检测两组患者卵泡数目和卵巢体积,评价两组患者中医证候评分,比较两组患者临床疗效。结果研究组INHB、AMH、NO水平低于对照组(P<0.05),研究组ET-1水平高于对照组(P<0.05),研究组LH、FSH、T水平低于对照组(P<0.05),研究组E_(2)水平高于对照组(P<0.05),研究组患者TC、TG、FPG、2 h PG水平低于对照组(P<0.05),研究组患者左侧卵巢体积、右侧卵巢体积、卵泡数目低于对照组(P<0.05),研究组患者中医证候主、次积分及总评分低于对照组(P<0.05),研究组总有效率为94.83%,研究组总有效率为81.03%,研究组总有效率高于对照组(P<0.05)。结论益肾柔肝法治疗正常体质量指数多囊卵巢综合征患者,可降低患者AMH、INHB水平,改善患者卵巢储备功能,降低患者卵巢体积和卵泡数目,改善患者多囊样改变,调节患者内分泌及代谢指标,调节患者血管活性物质,改善子宫微环境,缓解临床症状,提升临床疗效。

Objective To observe the effect of Yishen Rougan method on ovarian reserve function,polycystic changes,endocrine indexes and uterine microenvironment in patients with normal body mass index polycystic ovary syndrome.Methods 116 patients with normal BMI polycystic ovarian syndrome treated in hospital from December 2019 to December 2020 were selected as the study object.The patients were divided into groups according to the random digital table method,58 patients were the study group,58 patients were the control group,the control group was given ethinylestral and cycloproperone tablets.The study group combined with Bushen Rougan Decoction(补肾柔肝汤)on the basis of the control group.Both groups of patients were treated for 3 months and INHB,AMH,E_(2),FSH,LH,T,NO,ET-1,TC,TG,2 h PG were detected before and after treatment.The number of follicles and ovarian volume were measured by pelvic B-ultrasound.The TCM syndrome score of the two groups was evaluated and the clinical effect of the two groups was compared.Results The levels of INHB,AMH and NO in the study group were lower than those in the control group(P<0.05),the levels of ET-1 in the study group were higher than those in the control group(P<0.05),the levels of LH,FSH and T in the study group were lower than those in the control group(P<0.05),the levels of E_(2) in the study group were higher than those in the control group(P<0.05),and the levels of TC,TG,FPG and 2 h PG in the study group were lower than those in the control group(P<0.05).The volume of left ovary,the volume of right ovary and the number of follicles in the study group were lower than those in the control group(P<0.05),and the primary and secondary scores and total scores of TCM syndromes in the study group were lower than those in the control group(P<0.05).The total effective rate of the study group was 94.83%,the total effective rate of the study group was 81.03%,and the total effective rate of the study group was higher than that of the control group(P<0.05).Conclusion Yishen Rougan method can reduce the incidence of PCOS patients with normal body mass index AMH,INHB levels,improve ovarian reserve function,reduce ovarian volume and follicle number,improve polycystic changes,regulate endocrine and metabolic indicators,regulate vasoactive substances,improve uterine microenvironment,relieve clinical symptoms and improve clinical efficacy.