妊娠期母体胰岛β细胞功能适应性改变的研究进展

New advances on functional adaptation of maternal islet β cells during pregnancy

怀孕是人类繁衍的自然生理过程。随着妊娠进展,母体逐渐出现生理性IR。为维持血糖稳态,胰岛β细胞做出适应性改变,包括增加的胰岛β细胞质量和更高的胰岛素分泌率,胰岛β细胞适应不当导致糖代谢异常。本文对妊娠期母体胰岛β细胞功能适应性改变的研究进展进行综述。

Pregnancy is the natural process of human reproduction. With the progress of pregnancy,physiological IR gradually appeared in the mother. To maintain blood glucose homeostasis,islet β cell make adaptive changes,including increased islet β cell quality and higher insulin secretion rate. Improper cell adaptation in islet β cell leads to abnormal glucose metabolism. This paper reviews the research progress of adaptive changes of maternal islet β cell function during pregnancy.