基于微生物-肠-脑轴的粪菌移植抗抑郁的研究和展望

Antidepression with fecal bacteria transplantation based on microbiota-gut-brain axis:research and prospects

抑郁症是一种常见的精神疾病,病程持久且反复难愈,极大地影响了患者的正常生活。目前临床常规一线抗抑郁药物的疗效并不理想,亟待研发新的治疗方法。已有研究表明抑郁症与肠道菌群密切相关,微生物-肠-脑轴功能障碍是抑郁症的主要病理基础,是直接诱发和影响抑郁症的关键因素。以肠道微生物群为导向的抗抑郁治疗是目前最有前景的研究方向之一。本文主要介绍了肠道菌群与抑郁症的关系,以及粪菌移植在临床前和临床阶段抗抑郁的效果。

Depression is a common psychiatric disorder,which has persistent course,is repeatedly recurrent and difficult to heal,therefore greatly affects the normal life of patients.Currently,the conventional first-line antidepressants clinically used are not effective,and new therapies need to be developed urgently.Existing research shows that depression is closely related to gut microbiota.Microbiota-gut-brain axis dysfunction is the main pathological basis of depression and a key factor that directly induces and affects depression.Microbiota-orientated treatments are currently one of the most promising tracks.This article mainly introduces the relationship between gut microbiota and depression,and the results of fecal microbiota transplantation in the preclinical and clinical stages of antidepression.