生殖道微生态与宫颈HPV感染的相关性研究

Correlation between reproductive tract microecology and cervical HPV infection

宫颈癌作为最常见的女性恶性肿瘤之一,与人乳头瘤病毒(human papillomavirus,HPV)感染密切相关。近年来,随着对生殖道微生态研究的不断深入,我们逐渐认识到多种生殖道炎症与HPV感染及子宫颈上皮内瘤变有显著的相关性,而且细菌性阴道病相关致病菌在介导HPV感染及诱发宫颈病变中也发挥潜在作用。同时乳杆菌是健康女性阴道微环境中最常见的优势菌,对维持阴道微生态平衡及宫颈健康有着不可忽视的重要意义。因此,维持健康女性生殖道微生态环境对减少HPV持续感染和预防宫颈癌有重要的作用。本文将围绕生殖道微生态与HPV感染及子宫颈上皮内瘤变之间的相关性作一综述。

Cervical cancer,one of the most common female malignancies,is closely associated with human papillomavirus(HPV)infection.In recent years,with the deepening of the research on the microecology of reproductive tract,we have gradually realized that a variety of reproductive tract inflammation is significantly correlated with HPV infection and cervical intraepithelial neoplasia,and bacterial vaginosis related pathogens also play a potential role in mediating HPV infection and inducing cervical lesions.Meanwhile,lactobacillus,the most common dominant bacteria in the vaginal microenvironment of healthy women,is of great significance in maintaining the balance of vaginal microecology and cervical health.Therefore,maintaining healthy microecological environment of female reproductive tract plays an important role in reducing persistent HPV infection and preventing cervical cancer.This article will review the correlation between genital tract microecology and HPV infection as well as cervical lesions.