粪菌移植治疗溃疡性结肠炎的临床应用前景探讨

The prospect of clinical application of fecal microbiota transplantation in treating ulcerative colitis

溃疡性结肠炎(UC)是一种炎症性肠病(IBD),其病因尚不清楚,以慢性、反复复发、迁延不愈为特征,临床治疗效果欠佳。UC的病因和发病机制包括环境、遗传、微生物和免疫等因素,这些因素相互作用,增加肠上皮细胞通透性,最终导致过度的免疫反应。粪菌移植(FMT)作为一种重塑肠道菌群的治疗方法,可帮助肠道菌群失调的UC患者重建肠道新的肠道微生态。本文从肠道微生态角度出发,阐述FMT、肠道微生态和UC之间的联系,探讨目前FMT治疗UC的可能机制。

Ulcerative colitis(UC)is a type of inflammatory bowel disease(IBD).Its etiology is not known yet.It is characterized by chronic and repeated recurrence,and prolonged non-healing leisions,and the clinical treatment is not effective.The etiology and pathogenesis of UC include environmental,genetic,microbial,immune and other factors.These factors interact each other to increase the permeability of intestinal epithelial cells and ultimately lead to an excessive immune response.Fecal microbiota transplantation(FMT),as a treatment method to reestablish the intestinal flora,can help UC patients with intestinal flora disorders to rebuild a new intestinal microecology.From the perspective of intestinal microecology,this article explores the possible mechanisms of the current FMT treatment of UC through the connection among fecal microbiota transplantation,intestinal microecology,and ulcerative colitis.