左金丸合四逆散对溃疡性结肠炎炎症因子、YKL-40的影响研究

Changes of Inflammatory Factors and YKL-40 in Patients with Ulcerative Colitis Treated with Zuojin Pill(左金丸)and Sini Powder(四逆散)

目的研究左金丸合四逆散对溃疡性结肠炎患者炎症因子、甲壳质酶蛋白40(YKL-40)的影响。方法选取医院2018年10月—2020年6月收治的溃疡性结肠炎患者86例,分为两组各43例。对照组给予柳氮磺吡啶治疗,观察组给予左金丸合四逆散联合柳氮磺吡啶治疗,比较两组1个疗程后的疗效和不良反应,观察两组治疗前、1个疗程后肠镜下评分及血清因子的差异。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前肠镜下评分组间比较,差异无统计学意义(P>0.05)。观察组一个疗程后肠镜下评分低于对照组(P<0.05)。两组治疗前炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-23(IL-23)、白细胞介素-33(IL-33)]、YKL-40、血清低氧诱导因子-1α(HIF-1α)、基质金属蛋白酶-1(MMP-1)水平比较,差异无统计学意义(P>0.05)。观察组一个疗程后炎症因子、YKL-40、HIF-1α、MMP-1水平低于对照组(P<0.05)。两组不良反应率比较,差异无统计学意义(P>0.05)。结论左金丸合四逆散可减轻溃疡性结肠炎患者炎症反应,降低YKL-40、HIF-1α、MMP-1的表达水平,提高治疗效果,且不增加不良反应。

Objective To study the effects of Zuojin Pill(左金丸)and Sini Powder(四逆散)on the changes of inflammatory factors and chitinase protein 40(YKL-40)in patients with ulcerative colitis.Methods A total of 86 patients with ulcerative coli-tis admitted to the hospital from October 2018 to June 2020 were selected and divided into two groups,with 43 cases in each group.The control group was treated with sulfasalazine and the observation group was treated with Zuojin Pill and Sini Powder combined with sulfasalazine.The efficacy and adverse reactions of the two groups after a course of treatment were compared,and the colonoscopy scores of the two groups before and after a course of treatment were observed.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant comparison between the two groups under colonoscopy before treatment(P>0.05).After one course of treatment,the observation group's score under colonoscopy was lower than that of the control group(P<0.05).The lev-els of inflammatory factors[interleukin-1β(IL-1β),interleukin-23(IL-23),interleukin-33(IL-33)],YKL-40,serum hypoxia inducible factor-1α(HIF-1α)and matrix metalloproteinase-1(MMP-1)in two groups were not statistically signifi-cant(P>0.05).After one course of treatment,the levels of inflammatory factors,YKL-40,HIF-1αand MMP-1 in the ob-servation group were lower than those in the control group(P<0.05).The adverse reaction rates of the two groups were not sta-tistically significant(P>0.05).Conclusion Zuojin Pill and Sini Powder can alleviate the inflammatory response in patients with ulcerative colitis,reduce the expression levels of YKL-40,HIF-1αand MMP-1 and improve the therapeutic effect without in-creasing adverse reactions.