摘要
目的探讨华蟾素胶囊联合α干扰素对原发性小肝癌患者术后免疫功能和远期预后的影响。方法自2014年1月到2015年1月,收集我院行手术切除术的原发性小肝癌患者,共106例,随机分为观察组和对照组,每组53例,对照组给予α干扰素治疗;观察组给予α干扰素联合华蟾素胶囊治疗,持续18个月。比较两组患者免疫功能、远期预后差异。结果K-M生存曲线分析显示观察组患者生存时间显著高于对照组(P<0.05)。两组患者治疗前甲胎蛋白(alpha fetoprotein,AFP)水平、免疫球蛋白(immunoglobulin,Ig)A、IgM、IgG及补体C3、C4含量均无统计学差异(P>0.05)。治疗后与对照组比较,观察组患者AFP水平降低(21.89±1.56)vs(23.78±1.88)(P<0.05);IgA增高(1.65±0.05)vs(0.98±0.02)g/L(P<0.01);IgM增高(1.03±0.11)vs(0.91±0.13)g/L(P<0.01);IgG增高(12.44±1.08)vs(7.18±1.36)g/L(P<0.01);C3增高(1.25±0.0)vs(0.98±0.02)g/L(P<0.01);C4增高(0.23±0.01)vs(0.18±0.03)g/L(P<0.01)。结论华蟾素胶囊联合α干扰素对原发性小肝癌患者术后免疫功能和远期预后的改善作用疗效显著,具有一定的临床价值。
Objective To investigate the effects of cinobufotalin capsule combined with interferon alpha on postoperative immune function and long-term prognosis in patients with primary small hepatocellular carcinoma.Methods From January 2014 to January 2015,106 patients with primary small hepatocellular carcinoma who underwent surgical resection in our hospital were selected and randomly divided into observation group and control group,with 53 cases in each group.The control group were treated with interferon-α,the observation group was treated with cinobufotalin capsule combined with interferon-αfor 18 months.The differences of immune function and long-term prognosis were compared between the two groups.Results K-M survival curve analysis showed that the survival time of patients in the observation group was significantly higher than that in the control group(P<0.05).There were no significant differences in alpha fetoprotein(AFP),immunoglobulin(Ig)A,IgM,IgG,complement C3 and C4 between the two groups before treatment(P>0.05).After treatment,compared with the control group,AFP in the observation group decreased(21.891.56)vs(23.781.88),(P<0.05);IgA increased(1.650.05)vs(0.980.02)g/L,(P<0.01);IgM increased(1.03±0.11)vs(0.91±0.13)g/L,(P<0.01);IgG increased(12.44±1.08)vs(7.18±1.36)g/L,(P<0.01);C3 increased(1.25±0.0)vs(0.98±0.02)g/L,(P<0.01);C4 increased(0.23±0.01)vs(0.18±0.03)g/L,(P<0.01).Conclusion Cinobufotalin capsule combined with interferon-αhas a significant effect on the improvement of postoperative immune function and long-term prognosis in patients with small hepatocellular carcinoma,which has a certain clinical value.
作者
王琛
白桦
肖慧
宋云龙
WANG Chen;BAI Hua;XIAO Hui;SONG Yunlong(Chinese People's Liberation Army Rockel Army Characteristic Medicine Center Pharmacy Beijing 100088,China;Acupuncture Science,Guangwai Hospital in Xicheng Districtof Beijing.Beijing 100055,China;National Rehabilitation Aid Research Center Affliated Rehabilitation Hospital Pharmacy,Beijing 100176,China)
出处
《世界临床药物》
2022年第5期554-558,564,共6页
World Clinical Drug
基金
吴阶平医学基金(320.6750.18460)。
关键词
华蟾素胶囊
Α干扰素
原发性小肝癌
免疫功能
远期预后
cinobufotalin capsule
IFN-α
small hepatocellular carcinoma
immune function
long-term prognosis