养血安神法治疗失眠心脾两虚证的Meta分析

Meta-analysis of Effect of Nourishing Blood and Calming Nerves Method on Insomnia with Deficiency of Both Heart and Spleen

目的评价养血安神法治疗失眠心脾两虚证的临床疗效。方法按照循证医学要求,全面检索中国期刊全文数据库(CNKI)、万方数据库、维普中文期刊数据库(VIP)2010年1月—2020年12月的相关文献。把符合纳入标准的21篇文献作为Meta分析对象,选择临床疗效,PSQI评分,不良反应发生率作为效应指标,采用Cochrane协作网免费提供的Revman 5.3专用软件进行统计分析。结果临床疗效[OR=4.28,95%CI(3.24,5.64),P<0.00001];PSQI评分[MD=-3.90,95%CI(-4.60,-3.19),P<0.00001];不良反应发生率[OR=0.19,95%CI(0.13,0.29),P<0.00001]。三组比较均具有统计学意义,治疗组优于对照组。结论现有文献证据表明,养血安神法治疗失眠心脾两虚证有效。

Objective To evaluate the clinical efficacy of nourishing blood and calming nerves method in treating insomnia with deficiency of both heart and spleen.Methods According to the requirements of evidence-based medicine,the related literatures from January 2010 to December 2020 in China Journal Full-text Database(CNKI),Wanfang Database and VIP Chinese Journal Database were searched comprehensively.Twenty-one literatures which met in the criteria were selected as the objects of Meta-analysis.The clinical efficacy,PSQI score and incidence of adverse reactions were selected as the effect indicators,and Rev-man5.3 special software provided by Cochrane Collaboration Network was used for statistical analysis.Results The clinical effica-cy was significant[OR=4.28,95%CI(3.24,5.64),P<0.00001].The PSQI score was significant[MD=-3.90,95%CI(-4.60,-3.19),P<0.00001].The incidence of adverse reactions was significant[OR=0.19,95%CI(0.13,0.29),P<0.00001].The comparison among the three groups was statistically significant,and the treatment group was superior to the con-trol group.Conclusion The existing documentary evidence shows that the method of nourishing blood and calming nerves is effec-tive in treating insomnia with deficiency of both heart and spleen.