半夏厚朴汤加减治疗肺心病急性加重期合并胃肠道功能障碍的效果及不良反应分析

Analysis of the Effect and Adverse Reactions of Banxia Houpu Decoction in the Treatment of Acute Exacer‐bation of Pulmonary Heart Disease Complicated with Gastrointestinal Dysfunction

目的:探讨半夏厚朴汤加减治疗肺心病(PHD)急性加重期合并胃肠道功能障碍(GD)的效果。方法:选取我院2020年4月~2021年5月收治的PHD急性加重期+GD患者84例,按随机数字表法分为对照组和观察组各42例,对照组予以常规临床西医治疗,观察组在对照组基础上增加半夏厚朴汤加减治疗,比较两组肺功能、胃排空、血生化指标及不良反应情况。结果:治疗2周后,观察组第1秒用力呼气容积/用力肺活量(FEV1/FVC)、最大自主通气量(MVV)水平高于对照组(P<0.05);观察组胃窦收缩频率低于对照组(P<0.05),胃半排空时间长于对照组(P<0.05),胃窦运动指数高于对照组(P<0.05),胃窦收缩幅度大于对照组(P<0.05);观察组血浆胃动素(MTL)水平高于对照组,生长抑素(SS)、二胺氧化酶(DAO)水平低于对照组(P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:半夏厚朴汤加减治疗可改善PHD急性加重期+GD患者肺功能,调节胃肠动力,且不增加不良反应。

Objective:To investigate the effect of Banxia Houpu Decoction in the treatment of pulmonary heart disease(PHD)with gastrointestinal dysfunction(GD)during acute exacerbation.Methods:A total of 84 patients with acute exacerbation of PHD+GD who were admitted to our hospital from April 2020 to May 2021 were selected.According to the random number table method,they were divided into the control group of 42 cases and the observation group of 42 cases.The control group was given routine clinical western medicine treatment,and the observation group was added with Banxia Houpu Decoction on the basis of the control group.Biochemical indicators and adverse reactions.Results:After 2 weeks of treatment,the levels of forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC)and maximal spontaneous ventilation(MVV)in the observation group were higher than those in the control group(P<0.05);the contraction frequency of gastric antrum in the observation group was lower than that in the control group(P<0.05);The gastric half-emptying time in the observation group was shorter than that in the control group(P<0.05),the motility index of the gastric antrum was higher than that in the control group(P<0.05),and the contraction amplitude of the gastric antrum was greater than that in the control group(P<0.05).The levels of statin(SS)and diamine oxidase(DAO)were lower than those in the control group(P<0.05);there was no significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Banxia Houpu Decoction can improve the lung function and regulate gastrointestinal motility in patients with acute exacerbation of PHD+GD without increasing adverse reactions.