银花泌炎灵片治疗腺性膀胱炎的临床效果

Clinical effect of Yinhua Miyanling Tablets in treatment of cystitis glandularis

目的探讨银花泌炎灵片治疗腺性膀胱炎(CG)的效果。方法选择2016年1月至2021年3月解放军联勤保障部队第九八〇医院收治单纯行经尿道等离子电汽化切除术及术后联合膀胱灌注化疗的男性CG患者82例,按随机数字表法分为对照组和观察组,每组41例。对照组术后给予盐酸坦索罗辛缓释胶囊,观察组在此基础上加用银花泌炎灵片。治疗6个月,比较两组临床疗效,尿动力学指标(最大尿流率、平均尿流率和残余尿量)及血清炎症因子[白细胞介素-8(IL-8)、IL-17、肿瘤坏死因子α(TNF-α)]含量。结果观察组总有效率高于对照组(P<0.05)。治疗后,两组最大尿流率、平均尿流率高于治疗前,残余尿量少于治疗前(P<0.05);观察组最大尿流率、平均尿流率高于对照组,残余尿量少于对照组(P<0.05)。治疗后,两组IL-8、IL-17、TNF-α含量低于治疗前,且观察组低于对照组(P<0.05)。结论银花泌炎灵片对CG的治疗起到积极作用,可能与其抗炎作用有关。

Objective To investigate the effect of Yinhua Miyanling Tablets in the treatment of cystitis glandularis(CG).Methods A total of 82 male CG patients who underwent transurethral plasma vaporectomy and postoperative chemotherapy combined with bladder infusion were selected from January 2016 to March 2021 in the 980th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army.They were divided into control group and observation group according to the random number table method,with 41 cases in each group.The control group was given Tamsulosin Hydrochloride Sustained-Release Capsules after operation,and the observation group was additionally given Yinhua Miyanling Tablets on this basis.The treatment lasted for six months,the clinical efficacy,urodynamics indexes(maximum flow rate,average flow rate,residual urine volume),serum levels of inflammatory cytokines(interleukin-8[IL-8],IL-17 and tumor necrosis factor-α[TNF-α])were compared between two groups.Results The total effective rate in observation group was higher than that in control group(P<0.05).After treatment,the maximum flow rate and average flow rate of two groups were higher than those before treatment,while the residual urine volume was lower than that before treatment(P<0.05);the maximum flow rate and average flow rate in observation group were higher than those in control group,while the residual urine volume was lower than that in control group(P<0.05).After treatment,The levels of IL-8,IL-17,and TNF-αin two groups were lower than those before treatment,and observation group was lower than control group(P<0.05).Conclusion Yinhua Miyanling Tablets plays a positive role in the treatment of CG,which may be related to its anti-inflammatory effect.