摘要
目的观察复方紫连膏联合丁酸氢化可的松乳膏治疗脾虚湿蕴证亚急性婴幼儿湿疹的临床效果。方法选取河北中医学院附属沧州中西医结合医院皮肤科2020年12月至2021年7月脾虚湿蕴证亚急性婴幼儿湿疹患儿100例,根据随机数字表法分为治疗组和对照组,每组50例。对照组予以丁酸氢化可的松乳膏,治疗组在对照组的基础上应用复方紫连膏,治疗2周后,观察两组临床疗效;比较两组治疗前后湿疹面积及严重程度指数(EASI)评分、中医证候评分、经皮水分丢失值(TEWL)及不良反应;治疗结束后2周统计复发情况。结果治疗2周后,两组EASI评分、中医证候积分、TEWL低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗组复发率低于对照组,差异有统计学意义(P<0.05)。治疗期间两组均未出现明显不适,无不良事件发生。结论复方紫连膏联合丁酸氢化可的松乳膏可明显改善脾虚湿蕴证亚急性湿疹患儿的皮损和症状,具有较好的临床疗效,复发率低,值得临床推广和进一步研究。
Objective To observe the clinical effect of Fufang Zilian Ointment combined with Hydrocortisone Butyrate Cream in the treatment of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome.Methods A total of 100 cases of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome from December 2020 to July 2021 in Department of Dermatology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei University of Traditional Chinese Medicine were selected.They were divided into treatment group and control group,with 50 cases in each group.The control group was treated with Hydrocortisone Butyrate Cream,and treatment group was treated with Fufang Zilian Ointment on the basis of control group.After two weeks of treatment,the clinical efficacy of two groups was observed;eczema area and severity index(EASI)score,traditional Chinese medicine syndrome score,transepidermal waterloss(TEWL)and the occurrence of adverse reactions in two groups were compared;two weeks after the end of treatment,the recurrence rate was counted.Results After two weeks of treatment,EASI score,traditional Chinese medicine syndrome score and TEWL in two groups were lower than those before treatment,and treatment group was lower than control group,and the differences were statistically significant(P<0.05).The clinical efficacy of treatment group was better than that of control group,and the difference was statistically significant(P<0.05).The recurrence rate of treatment group was lower than that of control group,and the difference was statistically significant(P<0.05).No obvious discomfort and no adverse events occurred in the two groups during treatment.Conclusion Fufang Zilian Ointment combined with Hydrocortisone Butyrate Cream can significantly improve the skin lesions and symptoms of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome,with good clinical efficacy and low recurrence rate,which is worthy of clinical promotion and further research.
作者
宫克
郭建辉
杜凯晴
郭雯
张贤哲
张曼
崔雅欣
刘家瑶
GONG Ke;GUO Jianhui;DU Kaiqing;GUO Wen;ZHANG Xianzhe;ZHANG Man;CUI Yaxin;LIU Jiayao(Department of Dermatology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei University of Traditional Chinese Medicine,Hebei Province,Cangzhou061000,China;Graduate School,Chengde Medical College,Hebei Province,Chengde067000,China)
出处
《中国医药导报》
CAS
2022年第21期107-110,共4页
China Medical Herald
基金
河北省中医药管理局科研计划项目(2020461)。
关键词
亚急性湿疹
复方紫连膏
婴幼儿湿疹
临床观察
经皮水分丢失率
Subacute eczema
Fufang Zilian Ointment
Infantile eczema
Clinical observation
Transepidermal waterloss