痰热清注射液治疗卒中相关性肺炎的效果及对细菌清除的影响

Effect of Tanreqing Injection on the treatment of stroke-associated pneumonia and its effect on bacterial clearance

目的探讨痰热清注射液治疗卒中相关性肺炎(SAP)的效果及对细菌清除的影响。方法选择东南大学医学院附属南京同仁医院2018年7月至2021年4月收治的84例SAP患者为研究对象。按照随机数字表法分为观察组及对照组,每组42例。对照组给予头孢哌酮/舒巴坦治疗,观察组在对照组的基础上联合痰热清注射液治疗。治疗1周后评估两组中医证候评分、临床疗效、细菌清除情况、血清炎症因子水平[肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]及药物不良反应发生情况。结果治疗1周后,两组中医证候评分较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。病原菌总清除率高于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组TNF-α、IL-6、CRP水平较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论给予SAP患者痰热清注射液联合头孢哌酮/舒巴坦治疗,可有效提高患者的临床治疗效果,降低中医证候评分,提高病原菌清除率,降低炎症反应,安全性良好。

Objective To explore the effect of Tanreqing Injection on the treatment of stroke-associated pneumonia(SAP)and its effect on bacterial clearance.Methods A total of 84 SAP patients admitted to Nanjing Tongren Hospital,Southeast University School of Medicine from July 2018 to April 2021 were selected as the research subjects.They were divided into the observation group and the control group according to the random number table method,with 42 cases in each group.The control group was treated with Cefoperazone/Sulbactam,the observation group was treated with Tanreqing Injection on the basis of the control group.Traditional Chinese medicine syndrome score,clinical efficacy,bacterial clearance,serum inflammatory factor level(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6]and C-reaction protein[CRP])and the occurrence of adverse drug reactions were evaluated after one week of treatment.Results After one week of treatment,traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The total clearance rate of pathogens in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After one week of treatment,the levels of TNF-α,IL-6,and CRP in the two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of Tanreqing Injection combined with Cefoperazone/Sulbactam for SAP patients can effectively improve the clinical treatment effect of patients,reduce traditional Chinese medicine syndrome scores,increase pathogen clearance,reduce inflammation,and have good safety.