磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶在肿瘤中作用的研究进展

Research progress of the role of phospholysine phosphohistidine inorganic pyrophosphate phosphatase in tumor

磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶(LHPP)是调控组氨酸去磷酸化的重要的酶,主要在肝、脑、肾组织中表达,其与组氨酸激酶共同调控组氨酸残基的磷酸化与去磷酸化,该酶的缺失可破坏组氨酸残基的磷酸化与去磷酸化的平衡,导致PI3K/Akt、Wnt/β-catenin等一系列信号通路的异常活化,进而引起细胞周期蛋白、凋亡蛋白的异常,促进肿瘤的发生发展。LHPP对于肿瘤患者的早期筛查、早期诊断和治疗及预后具有重要意义,并有望成为患者个体化治疗的新治疗靶点和预后指标。本综述在以往文献研究的基础上,对LHPP在肝癌、胶质瘤、肾癌等部分肿瘤中的作用的研究进展进行了总结,旨在为LHPP在肿瘤中未来的研究方向和应用提供参考。

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP) is one of the important enzyme regulating histidine dephosphorylation, mainly expressed in liver, brain and kidney, and the regulation of histidine residues together with histidine kinase phosphorylation and dephosphorylation. The deletion of LHPP can destroy the balance between phosphorylation and dephosphorylation of histidine residues, resulting in PI3K/Akt and Wnt/β-catenin which, leads to the abnormality of cyclin and apoptotic protein, and promotes the occurrence and development of tumor.LHPP is significant for early screening, early diagnosis, treatment and prognosis of tumor patients, and it is expected to become a new therapeutic target and prognostic index for individualized treatment of patients. Based on the previous literature research, this review summarizes the research progress of the role of LHPP in some tumors such as liver cancer, glioma, and kidney cancer, in order to provide reference for the future research direction and application of LHPP in tumors.