基于CiteSpace中医药治疗肝纤维化的可视化分析

Visual analysis of traditional Chinese medicine in the treatment of hepatic fibrosis based on CiteSpace

目的 分析近40年的中医药治疗肝纤维化研究领域的研究现状、热点及趋势。方法 以中国知网、万方数据、维普数据库为数据来源,检索自1980年1月至2021年12月收录的中医药治疗肝纤维化相关的研究文献,利用CiteSpace 5.8.R3分析软件对检索到的文献进行发文量、作者、研究机构、关键词的可视化分析。结果 共纳入4469篇核心期刊文献,1997年以前属初起阶段,1998—2004年发文量开始快速增长,2005—2007年稍有回落,2008—2012年发文量维持在较高水平,2013—2015年有所回落,2016—2017年发文量短暂回升,2018—2021年较前略有下降。发文量≥9篇的核心作者有95名,主要有刘平、刘成海、刘成、徐列明、吕志平等。主要的研究机构是医学院校及其附属医院,其中广西中医药大学、上海中医药大学附属曙光医院、上海中医药大学为主要研究机构。频次排名前3位的关键词为大鼠、造血干细胞和肝硬化。关键词聚类可以分为3类:机制、实验和临床研究。突现强度最高的关键词为实验研究。结论 中医药在治疗肝纤维化方面实现了跨区域、跨机构间合作,未来研究热点将聚焦于中药单体及氧化应激、抗氧化、代谢组学等作用机制,以更好地推动肝纤维化领域的发展。

Objective To analyze the research status, hotspots, and trends of traditional Chinese medicine in the treatment of hepatic fibrosis in the past 40 years. Methods Articles related to the treatment of hepatic fibrosis with traditional Chinese medicine collected from January 1980 to December 2021 were searched by China national knowledge infrastructure, Wanfang Data, and VIP databases, and CiteSpace 5.8.R3 analysis software was used to perform visual analysis on the trend of the number of published articles, authors, research institutions, and keywords of the retrieved articles. Results A total of 4469 articles from core journals were included, it was in the initial stage before 1997, the number of articles published began to grow rapidly from 1998 to 2004, fell slightly from 2005 to 2007, remained at a high level from 2008 to 2012, fell slightly from 2013 to 2015, and rose briefly from 2016 to 2017. There was a slight decrease from 2018 to 2021. There were 95 core authors whose publications were ≥9, mainly Liu Ping, Liu Chenghai,Liu Cheng, Xu Liming, Lü Zhiping, etc. The main research institutions were medical colleges and affiliated hospitals,among Guangxi University of Chinese medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese medicine, and Shanghai University of Traditional Chinese Medicine were the main research institutions. The top three key words in frequency were rats, hematopoietic stem cells, and cirrhosis. Key words clustering could be divided into three categories: mechanism research, experimental research, and clinical research. The key words with the highest burst intensity were experimental research. Conclusion Traditional Chinese medicine in the treatment of hepatic fibrosis has realized the cross-regional, interagency cooperation, the research focus in the future will focus on traditional Chinese medicine monomer and oxidative stress, anti-oxidation, metabolomics, and other mechanisms, in order to better promote the development of liver fibrosis area.