摘要
目的:探讨急性胰腺炎患者血清甘油三酯(TG)、总胆固醇(TC)水平与发生全身炎性反应综合征(SIRS)、重症急性胰腺炎(SAP)的关系,为早期预防发生器官功能衰竭提供依据。方法:回顾性分析我院2015—2020年收治的319例急性胰腺炎患者,其中105例患者TG、TC水平均在正常值(设为A组),98例患者TG、TC水平均高于正常值(设为B组),66例患者仅TG水平高于正常值(设为C组),50例患者仅TC水平高于正常值(设为D组)。将C组按TG水平不同分为C1组(1.70mmol/L<TG≤5.64mmol/L)30例、C2组(5.65mmol/L≤TG≤11.30mmol/L)21例、C3组(TG>11.30mmol/L)15例。将D组按TC水平不同分为D1组(TC<5.2mmol/L)24例、D2组(5.2mmol/L≤TC<6.2mmol/L)16例、D3组(TC≥6.2mmol/L)10例。收集所有患者的性别、年龄、体重指数(BMI)、TG、TC、改良马歇尔(Marshall)评分等数据进行比较分析。结果:B组、C组、D组SIRS、SAP发生率均明显高于A组(P<0.05),同时B、C组SIRS、SAP发生率明显高于D组(P<0.05)。C1组、C2组、C3组SIRS发生率均明显高于A组(P<0.05),且随着TG升高,SIRS、SAP发生率也随之升高。D1组、D2组SIRS、SAP发生率与A组相比无明显差异,D3组SIRS、SAP发生率显著高于A组(P<0.05)。结论:TG、TC升高是导致急性胰腺炎患者发生SIRS、SAP的危险因素,其中TG与SIRS、SAP发生率呈正相关,TC≥6.2mmol/L时患者发生SIRS、SAP的风险明显升高。
Objective:To explore the relationship between serum triglyceride(TG)and total cholesterol(TC)levels in patients with acute pancreatitis and the occurrence of systemic inflammatory response syndrome(SIRS)and severe acute pancreatitis(SAP).Methods:A retrospective analysis of 319 patients with acute pancreatitis who were hospitalized in our hospital from 2015 to 2020.Among them,the serum TG and TC values of 105 patients were in the normal range(set as group A),the serum TG and TC values of 98 patients were greater than the normal value(set as group B),the serum TG value of 66 patients increased and the TC value was normal(set as group C),and the serum TC value of 50 patients increased and the TG value was normal(set as group D).Group C was divided into 30 cases in group C1(1.70mmol/L<TG≤5.64 mmol/L),21 cases in group C2(5.65mmol/L≤TG≤11.30mmol/L)and 15 cases in group C3(TG>11.30mmol/L).Group D was divided into 24 cases in group D1(TC<5.2mmol/L),16 cases in group D2(5.2mmol/L≤TC<6.2mmol/L)and 10 cases in group D3(TC≥6.2mmol/L).The data of gender,age,body mass index(BMI),TG,TC and modified Marshall score of all patients were collected for comparative analysis.Results:The incidence of SIRS and SAP in group B,C,and D was significantly higher than that in group A(P<0.05),meanwhile,the incidence of SIRS and SAP in group B and C was significantly higher than that in group D(P<0.05).The incidence of SIRS in group C1,C2,and C3 was significantly higher than that in group A(P<0.05),and with the increase of TG,the incidence of SIRS and SAP also increased.The incidence of SIRS and SAP in group D1 and D2 was not significantly different from that in group A,but the incidence of SIRS and SAP in group D3 was significantly higher than that in group A(P<0.05).Conclusion:Elevated TG and TC are the risk factors for SIRS and SAP in patients with acute pancreatitis.Among them,TG is positively correlated with the incidence of SIRS and SAP.When TC≥6.2mmol/L,the risk of SIRS and SAP in patients is significantly increased.
作者
姚敦卫
余贤恩
覃敏珍
黄培宁
黄钜略
罗暇
冯梦蝶
韦凯扬
YAO Dunwei;YU Xian’en;QIN Minzhen(Department of Gastroenterology,Baise People’s Hospital,Baise City,Guangxi 533000;不详)
出处
《医学理论与实践》
2022年第15期2533-2535,共3页
The Journal of Medical Theory and Practice
基金
百色市科学研究与技术开发计划课题(百科20184403)。
关键词
急性胰腺炎
甘油三酯
胆固醇
全身炎性反应综合征
Acute pancreatitis
Triglycerides
Cholesterol
Systemic inflammatory response syndrome