激素替代疗法联合坤泰胶囊治疗绝经高危人乳头状瘤病毒感染的临床效果

Clinical effect of hormone replacement therapy combined with Kuntai Capsules in the treatment of menopausal high-risk human papillomavirus infection

目的探讨激素替代疗法联合坤泰胶囊治疗绝经高危人乳头状瘤病毒感染(HPV)的临床效果。方法回顾性分析2020年7月至12月江西省德兴市妇幼保健院收治的64例绝经HPV感染患者的临床资料,按照不同的治疗方案将患者分成观察组(34例)和对照组(30例)。对照组患者给予阴道塞药治疗,观察组患者在对照组基础上给予激素替代疗法联合坤泰胶囊治疗。比较两组患者的转阴疗效、免疫功能。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的CD4^(+)高于治疗前,CD8^(+)低于治疗前,观察组患者治疗后的CD4^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05)。结论绝经HPV感染患者给予激素替代疗法联合坤泰胶囊治疗,能够提高转阴疗效,增强患者免疫功能。

Objective To investigate the clinical effect of hormone replacement therapy combined with Kuntai Capsules treatment in menopausal patients with high-risk human papillomavirus(HPV)infection.Methods A retrospective analysis of the clinical data of 64 postmenopausal HPV-infected patients admitted to Dexing Maternal and Child Health Hospital of Jiangxi Province from July to December 2020.They were divided into the observation group(34 cases)and the control group(30 cases)according to different treatment plans,the control group was treated with vaginal plugs,and the observation group was treated with hormone replacement therapy combined with Kuntai Capsules^(+)vaginal plugs.The efficacy and immune function of the two groups of patients were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The CD4^(+)levels of patients of the two groups after treatment were higher than those before treatment,and the CD8^(+)levels of patients of the two groups after treatment were lower than before treatment,the CD4^(+)after treatment of patients in the observation group was higher than that of the control group,CD8^(+)of patients in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion The treatment of menopausal HPV infection with hormone replacement therapy combined with Kuntai Capsules can improve the curative effect of negative conversion and enhance the immune function of patients.