腹腔镜下垂体后叶素水分离剥除术在卵巢囊肿患者中的应用效果

Application effect of laparoscopic pituitrin water separation and exfoliation in patients with ovarian cysts

目的探讨腹腔镜下垂体后叶素水分离剥除术治疗卵巢囊肿(OC)的效果及对患者卵泡质量、激素水平、并发症的影响。方法选取2020年1月至12月厦门市第五医院收治的80例OC患者为研究对象,采用随机数字表法将其分为观察组(n=40)和对照组(n=40)。对照组采用常规腹腔镜下囊肿剥除术治疗,观察组采用腹腔镜下垂体后叶素水分离剥除术治疗。比较两组患者术前、术后的卵泡质量[血清瘦素(LEP)、总抗氧化力(TAC)、血管内皮生长因子(VEGF)]、窦状卵泡数(AFC)、激素水平[雌二醇(E2)、促黄体生成素(LH)、卵泡刺激素(FSH)]变化情况,并统计两组患者的术后并发症发生情况及1年内妊娠率。结果术前,两组患者的卵泡质量指标、AFC、激素水平比较,差异无统计学意义(P>0.05);术后,观察组的LEP、VEGF、E2、LH、FSH水平低于对照组、TAC、AFC水平高于对照组,差异有统计学意义(P<0.05)。观察组术后的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。观察组的1年内妊娠率高于对照组,差异有统计学意义(P<0.05)。结论腹腔镜下垂体后叶素水分离剥除术治疗OC对改善患者卵泡质量、激素水平均有积极作用,经该术式治疗后,患者术后并发症发生风险更低,成功妊娠率更高。

Objective To explore the effect of laparoscopic pituitrin water separation and exfoliation in the treatment of ovarian cysts(OC)and its influence on the quality of patients′follicles,hormone levels and complications.Methods A total of 80 OC patients admitted to Xiamen Fifth Hospital from January to December 2020 were selected as the research objects,and they were divided into the observation group(n=40)and the control group(n=40)according to random number table method.The control group was treated with conventional laparoscopic cystectomy,and the observation group was treated with laparoscopic pituitrin water separation and exfoliation.The changes of follicle quality(serum leptin[LEP],total antioxidant capacity[TAC],vascular endothelial growth factor[VEGF]),the number of antral follicles[AFC],hormone levels(estradiol[E2],luteinizing hormone[LH],follicle stimulating hormone[FSH])before and after operation were compared between the two groups,the incidence of postoperative complications and the pregnancy rate within one year in the two groups were statistically analyzed.Results Before operation,there were no significant difference in follicular quality index,AFC,and hormone levels between the two groups of patients(P>0.05).After operation,the levels of LEP,VEGF,E2,LH and FSH in the observation group were lower than those in the control group,and the levels of TAC and AFC in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The pregnancy rate within one year in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Laparoscopic pituitrin water separation and exfoliation in the treatment of OC has a positive effect on improving the quality of follicles and hormone levels in patients.After this surgical treatment,the risk of postoperative complications is lower and the rate of successful pregnancy is higher.