肠易激综合征生物标志物研究进展

Research progress on biomarkers of irritable bowel syndrome

肠易激综合征(IBS)是以脑-肠调节紊乱,内脏高敏感性为特征的慢性消化系统常见疾病,也是公认的一种具有特殊病理生理基础的心身疾病。其诊断主要依赖罗马Ⅳ诊断标准,该标准主观性较强,容易造成误诊或者漏诊。因此,寻找一种诊断效能较高的生物学标记物是目前IBS临床诊疗面临的挑战之一。现从血液生物标志物、粪便生物标志物、结肠黏膜免疫标志物、病原体标志物和分子生物学标志物5个方面,就近年来IBS相关生物标志物的研究现状作一综述,以期为临床工作者更好的了解和应用提供帮助。

Irritable bowel syndrome(IBS)is a common chronic digestive disease characterized by brain gut regulation disorder and visceral hypersensitivity.It is also recognized as a psychosomatic disease with special pathophysiological basis.Its diagnosis mainly depends on RomeⅣdiagnostic standard,which is highly subjective and easy to cause misdiagnosis or missed diagnosis.Therefore,finding a biomarker with high diagnostic efficiency is one of the challenges faced by the clinical diagnosis and treatment of IBS.This paper reviews the research status of IBS related biomarkers in recent years from five aspects:blood biomarkers,fecal biomarkers,colonic mucosal immune markers,pathogen markers and molecular biomarkers,in order to provide help for clinical workers to better understand and apply.