实脾饮合肾气丸治疗慢性肾功能衰竭

Efficacy of Shipi Drink Combined with Shenqi Pills in Treatment of Chronic Renal Failure

目的:观察实脾饮合肾气丸治疗慢性肾功能衰竭患者的临床疗效,并分析其对患者免疫功能的影响。方法:162例肾功能衰竭患者按照随机数字表法平均分为对照组和观察组。对照组给予常规对症治疗,观察组在对照组治疗基础上给予实脾饮合肾气丸,两组均治疗3个月。比较两组患者临床疗效和不良反应,治疗前后中医证候积分、肾功能以及免疫功能。结果:观察组有效率高于对照组(92.59%vs 76.54%),两组比较,差异有统计学意义(P<0.05)。治疗后,观察组、对照组倦怠乏力[(0.61±0.13)分vs(1.45±0.25)分]、腰膝酸软[(0.72±0.19)分vs(1.34±0.35)分]、食少纳呆[(0.62±0.12)分vs(1.43±0.16)分]、畏寒肢冷积分[(0.51±0.19)分vs(1.21±0.28)分],血清尿素氮[(15.11±4.74)mmol·L^(-1) vs(19.35±3.65)mmol·L^(-1)]、血肌酐[(201.41±20.69)μmol·L^(-1) vs(235.15±23.15)μmol·L^(-1)]、IgA[(1.87±0.35)g·L^(-1) vs(2.53±0.41)g·L^(-1)]、IgG[(11.92±2.64)g·L^(-1) vs(13.86±3.42)g·L^(-1)]、IgM[(1.36±0.32)g·L^(-1) vs(1.82±0.62)g·L^(-1)]、IgE[(152.34±15.28)g·L^(-1) vs(171.31±23.31)g·L^(-1)]水平比较,差异均有统计学意义(P<0.05);观察组内生肌酐清除率高于对照组[(38.13±6.33)mL·min^(-1)vs(32.34±4.16)mL·min^(-1)](P<0.05)。结论:实脾饮合肾气丸治疗慢性肾功能衰竭临床疗效显著,可显著改善慢性肾功能衰竭患者免疫功能,提高肾功能。

Objective:To observe the clinical efficacy of Shipi Drink and Shenqi Pills in the treatment of patients with chronic renal failure,and to analyze its influence on the immune function of patients.Methods:162 patients with renal failure were equally divided into the control group and the observation group according to the random number table method.The control group was given routine symptomatic treatment,and the observation group was given Shipi Drink combined with Shenqi Pills on basis of the treatment of the control group,both groups were treated for 3 months.The clinical efficacy,adverse reactions,TCM syndrome scores,renal functions and immune functions before and after treatment were compared between the two groups.Results:The effective rate of the observation group was higher than that of the control group(92.59%vs 76.54%),and the difference was statistically significant(P<0.05).After treatment,the observation group and the control group suffered from fatigue[(0.61±0.13)points vs(1.45±0.25)points],soreness and weakness of the waist and knees[(0.72±0.19)points vs(1.34±0.35)points],poor appetite[(0.62±0.12)points vs(1.43±0.16)points],chills scores[(0.51±0.19)points vs(1.21±0.28)points],serum BUN[(15.11±4.74)mmol·L^(-1) vs(19.35±3.65 mmol·L^(-1))],SCr[(201.41±20.69)μmol·L^(-1) vs(235.15±23.15)μmol·L^(-1)],IgA[(1.87±0.35)g·L^(-1) vs(2.53±0.41 g·L^(-1))],IgG[(11.92±2.64)g·L^(-1) vs(13.86±3.42)g·L^(-1)],IgM[(1.36±0.32)g·L^(-1) vs(1.82±0.62)g·L^(-1)],IgE[(152.34±15.28)g·L^(-1) vs(171.31±23.31)g·L^(-1)]levels,the differences were statistically significant(P<0.05);within the observation group The creatinine clearance rate was higher than that of the control group[(38.13±6.33)mL·min^(-1)vs(32.34±4.16)mL·min^(-1)](P<0.05).Conclusion:Shipi Drink and Shenqi Pills have significant clinical efficacy in the treatment of chronic renal failure,and it can significantly improve the immune function and renal function of patients with chronic renal failure.