龙胆泻肝汤加减联合卡泊三醇倍他米松凝胶治疗成人头皮银屑病临床研究

Clinical Study on Modified Longdan Xiegan Decoction(龙胆泻肝汤)Combined with Calcipotriol Betamethasone Gel in Treatment of Adult Scalp Psoriasis

目的:观察龙胆泻肝汤加减联合卡泊三醇倍他米松凝胶治疗成人头皮银屑病的疗效及安全性。方法:选取成人头皮银屑病患者80例,按随机数字表法分为对照组和治疗组各40例。对照组仅使用卡泊三醇倍他米松凝胶治疗,治疗组在对照组基础上加用龙胆泻肝汤加减治疗,两组均以4周为1个疗程,连续治疗2个疗程。比较两组患者治疗前后的银屑病严重程度指数(PSSI)评分、皮肤病生活质量指数(DLQI)评分,以及疾病严重程度分布情况,并统计两组治疗期间的不良反应情况。结果:治疗后,两组患者的PSSI、DLQI评分较治疗前均降低,差异有统计学意义(P<0.01)。治疗8周后,治疗组患者PSSI评分、DLQI评分均低于对照组,轻度患者比例高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均无严重不良反应事件发生。结论:龙胆泻肝汤加减联合局部外用卡泊三醇倍他米松凝胶治疗头皮银屑病具有良好的疗效及安全性。

Objective:To observe the efficacy and safety of modified Longdan Xiegan Decoction(龙胆泻肝汤)combined with calcipotriol betamethasone gel in the treatment of adult scalp psoriasis.Methods:A total of 80 adult patients with scalp psoriasis were divided into control group and treatment group according to the random number table method,with 40 cases in each group.The control group was only treated with calcipotriol betamethasone gel,while the treatment group was treated with medified Longdan Xiegan Decoction on the basis of the control group.Both the two groups took 4 weeks as a course of treatment,and were continuously treated for 2 courses.After treatment,the psoriasis severity index(PSSI)score,dermatological life quality index(DLQI)score and classification of disease severity before and after treatment of the patients in the two groups were compared,and the adverse reactions during the treatment period of the two groups were recorded.Results:After treatment,the PSSI score and DLQI score of the patients in the two groups were lower than those before the treatment(P<0.01).After 8 weeks of treatment,the PSSI score and DLQI score of the patients in the treatment group were lower than those of the patients in the control group,and the proportion of patients with moderate scalp psoriasis in the treatment group was higher than that in the control group(P<0.05).No serious adverse reactions occurred in both the two groups during treatment.Conclusions:Modified Longdan Xiegan Decoction combined with topical application of calcipotriol betamethasone gel has good curative efficacy and safety in the treatment of scalp psoriasis.