基于核酸放大技术的光学生物传感器在疾病诊断中的研究进展

Recent advances in nucleic acid amplification-based optical biosensors for disease diagnosis

光学生物传感器因具有操作简便、响应速度快、灵敏度高及结果可视化等优点,已被广泛用于疾病标志物的分析检测。在构建光学生物传感器时,利用核酸放大技术提高光学生物传感器的分析性能,可实现生物标志物的高灵敏检测,为疾病诊断提供更加精准的依据。本文综述了近年来基于核酸放大技术的光学生物传感器在疾病诊断中的研究进展,提出了在实际应用中可能存在的问题并对未来发展趋势进行展望。

Optical biosensors have been widely used in the detection of biomarkers due to their advantages of simple operation,quick response,high sensitivity and visualization.When constructing optical biosensors,nucleic acid amplification technology can be used to improve the analytical performance of optical biosensor,which can further realize the highly sensitive detection of biomarkers and provide more accurate information for disease diagnosis.In this review,recent advances in nucleic acid amplification-based optical biosensors for disease diagnosis were reviewed,the possible problems may exist in practical applications,and future development trends were proposed.