调控炎症的脂肪因子在非酒精性脂肪性肝病中的作用机制

Mechanisms of Adipokines Regulating Inflammation in Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)是一种肝脏慢性代谢性疾病,是代谢综合征的肝脏表现。脂肪因子是脂肪组织分泌的多种生物活性肽或蛋白质的统称,通过自分泌和旁分泌的方式调节脂肪组织功能,并通过内分泌的方式参与全身其他脏器的代谢、炎症与免疫等生理活动的调节。肥胖状态下脂肪因子谱的改变则与各种代谢性疾病的发生相关。脂肪因子在NAFLD发病与进展中发挥重要作用,通过多种细胞机制直接或间接地参与肝脏炎症的调控。对脂肪因子的深入研究丰富了人们对NAFLD发病机制的认知,随着更多证据的出现,脂肪因子或可成为治疗NAFLD的新靶标。

Non-alcoholic fatty liver disease(NAFLD)is a chronic metabolic disease of liver,which is regarded as a manifestation in liver of the metabolic syndrome.Adipokine is a collective term for the biologically active peptides or proteins secreted by adipose tissue.It regulates the function of adipose tissue in an autocrine and paracrine manner,while participates in the regulation of physiological activities including metabolism,inflammation and immunity etc.of other organs in the whole body in an endocrine manner.Changes in the adipokines profile caused by obesity are involved in the pathogenesis of a series of metabolic diseases.Adipokines play an important role in the pathogenesis and progression of NAFLD,regulating liver inflammation through a variety of cellular mechanisms directly or indirectly.In-depth research on adipokines has enriched the understanding of the pathogenesis of NAFLD.With more evidence being discovered,adipokines may become a new target for the treatment of NAFLD in the future.