脑小血管病相关抑郁症的危险因素与机制研究进展

Research Progress in Risk Factors and Mechanism of Depression Associated with Cerebral Small Vessel Disease

脑小血管病(CSVD)是脑内小血管病变所导致的一种复杂的临床影像病理综合征,其特征主要包括腔隙性梗死、白质异常、脑微出血和脑萎缩,临床表现为认知功能下降、情感障碍等。由于CSVD患者常伴随情感行为与精神情绪的异常,被认为是诱发抑郁症的常见原因。CSVD诱发抑郁的危险因素可能涉及年龄、性别、肥胖等因素,而其发生机制主要与免疫反应、血脑屏障破坏、神经传导通路损伤、神经元生理功能改变等紧密相关。因此,对CSVD相关抑郁症的危险因素与机制进行深入研究,可进一步提升和丰富CSVD相关抑郁症的防治。

Cerebral small vessel disease(CSVD)is a complex clinical imaging pathological syndrome,featured with lacunar infarction,white matter abnormalities,cerebral hemorrhage and brain atrophy,and the clinical manifestations include cognitive decline,emotional disorders and other symptoms.Because CSVD patients are often accompanied by abnormal emotional behavior and mental emotion,it is considered to be a common cause of depression.The risk factors of CSVD induced depression may involve age,gender,obesity and other factors,and its mechanism is closely related to immune response,destruction of blood-brain barrier,damage of nerve conduction pathway,changes of neuronal physiological function and so on.Therefore,an in-depth study on the risk factors and mechanisms of CSVD related depression can further improve and enrich the prevention and treatment of CSVD related depression.