良性前列腺增生与膀胱癌相关性的研究进展

Research Progress of Correlation between Benign Prostate Hyperplasia and Bladder Cancer

良性前列腺增生(BPH)是老年男性常见的泌尿系统疾病,也是导致老年男性发生排尿困难的最常见原因之一。作为泌尿系统第二大肿瘤,膀胱癌在男性中的发病率、病死率均显著高于女性。目前临床上BPH共病膀胱癌的现象并不少见,且BPH与膀胱癌密切相关,其可能的潜在机制包括致癌暴露、性激素、炎症通路、微生物菌群失调、细胞焦亡以及氧化应激等。因此,通过治疗BPH减少膀胱癌的发生具有重要意义,可以为膀胱癌的预防和治疗提供新的思路。

Benign prostatic hyperplasia(BPH)is a common urinary system disease in older men,and it is one of the most common causes of dysuria.Bladder cancer,as the second largest tumor of the urinary system,has significantly higher morbidity and mortality in men than in women.At present,the phenomenon of clinical BPH comorbidity of bladder cancer is not uncommon,and BPH is closely associated with bladder cancer.The possible potential mechanisms include carcinogenic exposure,sex hormones,inflammatory pathways,microbial flora imbalance,pyroptosis and oxidative stress,etc.Therefore,it is of great significance to reduce the occurrence of bladder cancer through the treatment of BPH patients,which may provide new ideas for the prevention and treatment of bladder cancer.