微RNA调控糖代谢的研究进展

Research Progress in MicroRNA Regulating Glucose Metabolism

糖代谢在机体生理过程中发挥重要作用,糖代谢紊乱是导致糖尿病等代谢性疾病的主要病因。微RNA(miRNA)是一种参与基因表达调控的非编码RNA,通过抑制下游基因表达行使其生物学功能,miRNA可通过干预胰岛β细胞功能、调节胰岛素的合成与分泌、调控胰岛素信号转导等途径影响糖代谢,直接或间接参与糖尿病等相关代谢性疾病的发生发展。深入研究miRNA对糖代谢的影响,有利于对糖尿病等相关代谢性疾病的精准靶向防治。

Glucose metabolism plays an important role in the body′s physiological process.Disorders of glucose metabolism are the main cause of diabetes and other metabolic diseases.MicroRNA(miRNA)is a type of non-coding RNA involved in the regulation of gene expression,which performs its biological functions by inhibiting downstream gene expression.Studies have shown that miRNA can affect glucose metabolism through various pathways such as interfering withβcell function,regulating the synthesis and secretion of insulin,and regulating insulin signaling,thus directly or indirectly participate in the occurrence and development of diabetes and other related metabolic diseases.In-depth study of the role of miRNA in glucose metabolism is conducive to precise targeted prevention and treatment of diabetes and other related metabolic diseases.