转化生长因子-β与高度近视脉络膜新生血管病变关系的研究进展

Research Progress in Relationship between Transforming Growth Factor-β and Choroidal Neovascularization in High Myopia

高度近视是世界范围内造成视力受损的常见眼病,发病率呈上升趋势,而黄斑区脉络膜新生血管(CNV)是高度近视的并发症之一,也是导致患者失明的主要原因,可明显降低患者的生存质量。转化生长因子-β(TGF-β)作为调节细胞增殖、分化、运动、凋亡的重要因子,通过信号通路、浓度梯度、内皮细胞间充质转化、受体CD105表达等途径调控视网膜/脉络膜新生血管的生成,并在高度近视中发挥巩膜重塑作用,通过促进或抑制其他因子的表达促进近视发展。TGF-β与高度近视CNV密切相关,有望成为治疗高度近视及CNV病变的新靶点。

High myopia is a common eye disease that causes visual impairment worldwide,and the incidence is on the rise.And macular choroidal neovascularization(CNV)is one of the complications of high myopia and the main cause of blindness in the patients,which can significantly reduce the quality of life of the patients.Transforming growth factor-β(TGF-β),as an important factor regulating cell proliferation,differentiation,movement and apoptosis,regulates retinal/chorioneovascularization through signaling pathway,concentration gradient,endothelial mesenchymal transformation,receptor CD105 expression and other pathways,and plays a role of scleral remodeling in high myopia,thus promotes the development of myopia by promoting or inhibiting the expression of other factors.TGF-βis closely related to CNV in high myopia,and is expected to become a new target for the treatment of high myopia and CNV lesions.