炎症因子在肠道菌群与慢性阻塞性肺疾病间作用的研究进展

Research Progress on the Role of Inflammatory Factors in Intestinal Flora and Chronic Obstructive Pulmonary Disease

肠道菌群是长期存在于人体肠道内的一种微生物群落。正常的肠道微生物群可帮助机体执行多种理化功能,包括宿主防御、免疫调节以及维持肠道黏膜屏障结构完整性和体内平衡等。肠道微生物群也可通过改变肺部免疫防御影响肺部健康,慢性阻塞性肺疾病(COPD)患者常伴有肠道菌群紊乱,肠道微生物可能通过影响白细胞介素(IL)-6、肿瘤坏死因子-α、IL-33、一氧化氮、基质金属蛋白酶9等炎症因子的表达加重或延缓COPD的发展。因此,深入研究炎症因子在肠道菌群对COPD影响中的作用,有助于优化临床COPD治疗方案,为COPD患者的治疗提供新思路。

Gut microbiota is a long-standing microbial community in human intestine.Normal gut microbiota can help to perform a variety of physichemical functions,including host defense,immune regulation and maintaining the structural integrity and balance of intestinal mucosal barrier.Gut microflora can also affect lung health by changing lung immune defense.The interaction between the intestine and the lungs is called the intestinal-lung axis.Patients with chronic obstructive pulmonary disease(COPD)are often accompanied by intestinal flora disorder.Gut microorganisms may aggravate or delay the development of COPD by affecting inflammatory factors,such as interleukin(IL)-6 and tumor necrosis factor-α,IL-33,nitric oxide and matrix metalloproteinase-9.Therefore,in-depth study of the effect of inflammatory factors on COPD in the intestinal flora is helpful to optimize the clinical treatment plan,and provide new ideas for the treatment of COPD patients.