川崎病急性期相关的生物标志物研究进展

Advances in Study of Biomarkers Related to Acute Phase of Kawasaki Disease

川崎病是一种自限性疾病,主要侵害冠状动脉,严重影响婴幼儿日后的生长发育。在川崎病急性期能够辨别、诊断并及时治疗是改善川崎病预后的关键。目前,关于川崎病的临床诊断、治疗和长期随访管理方面已有详细的指南。与川崎病相关的炎症、蛋白质组、基因表达和基于微RNA的生物标志物研究越来越多,有助于川崎病的诊断。但以上生物标志物尚处于研究的早期阶段,且诊断的灵敏度和特异度均不能满足临床需要,未来需要进一步研究,探索适用于临床的生物标志物,以期早期诊断和治疗川崎病。

Kawasaki disease is a self-limited disease that mainly affects the coronary arteries,seriously affects the growth and development of infants in the future.Therefore,the identification,diagnosis and timely treatment of Kawasaki disease in the acute stage are the key to improve the prognosis.Currently,there are detailed guidelines for the clinical diagnosis,treatment and long-term follow-up management of Kawasaki disease.There is an increasing number of studies on inflammation,proteome,gene expression and microRNA-based biomarkers related to Kawasaki disease,which is helpful to the diagnosis.However,the above biomarkers are still in the early stage of research,and the diagnostic sensitivity and specificity cannot meet the clinical needs.Therefore,further studies are needed in the future to explore clinically applicable biomarkers for the early diagnosis and treatment of Kawasaki disease.