sJIA-MAS的早期识别信号

Early Diagnosis of Systemic Juvenile Idiopathic Arthritis Combined with Macrophage Activation Syndrome

巨噬细胞活化综合征(MAS)是风湿免疫性疾病中一种较危急的综合征,常继发于全身型幼年特发性关节炎(sJIA)。MAS常可累及全身多器官系统,若不及时诊治可导致高致残率。sJIA与MAS在发病机制、临床表现以及实验室检查指标方面均存在相似性,增加了sJIA与MAS的区分难度。但实际上MAS的炎症反应更剧烈,一旦炎症风暴发生,其临床表现和实验室检查指标变化会更明显。因此,深入研究sJIA与MAS的临床特征和实验室指标,可以为早期识别MAS提供理论基础。

Macrophage activation syndrome(MAS)is a relatively critical syndrome in rheumatic immune diseases,most often complicated by systemic juvenile idiopathic arthritis(sJIA).MAS often involves multiple organ systems throughout the body,and if not diagnosed and treated in time,it can lead to a high disability rate.There are similarities between sJIA and MAS in terms of pathogenesis,clinical manifestations and laboratory test indicators,which increases the difficulty of differentiating sJIA and MAS.But in fact,the inflammatory response of MAS is more severe,and once the inflammatory storm occurs,the changes of clinical manifestations and laboratory indicators are more obvious.Therefore,in-depth study of the clinical features and laboratory indicators of sJIA and MAS can provide a theoretical basis for the early identification of MAS.