摘要
In recent years,large animal models of naturally occurring diseases have become increasingly studied,with the rationale that their disease attributes may better recapitulate the pathological features of corresponding human diseases as compared to induced disease models(Hoffman and Dow,2016).Of the available naturally occurring disease models,the canine is increasingly recognized as a valuable pre-clinical animal model in translational medicine for numerous human diseases,including cancer.
基金
provided by the Center for Companion Animal Health and UC Davis Veterinary Institute of Regenerative Cures(VIRC),School of Veterinary Medicine,University of California,Davis
grants from the National Institutes of Health(1R01NS115860-01A1,5R01NS100761-02)
the Shriners Hospitals for Children(85108-NCA-19,85135-NCA-21)
supported by the Willis W.and Ethel M.Clark Foundation Investment in Community Fellowship
the Lodric Maddox Graduate Fellowship
the National Center for Advancing Translational Sciences,National Institutes of Health,through grant number UL1 TR001860
linked award TL1 TR001861。
