GBV-C病毒感染与非霍奇金淋巴瘤及霍奇金淋巴瘤关系的meta分析

Meta analysis of the association between GBV-C virus infection and non-Hodgkin lymphoma and Hodgkin lymphoma

目的探讨人类GB病毒C型(GBV-C)病毒感染与非霍奇金淋巴瘤(NHL)和霍奇金淋巴瘤(HL)的关系。方法计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库中关于GBV-C病毒感染与NHL及HL关系的文献。检索时间1990年1月至2021年7月。两名研究者独立筛选文献,提取数据及文献评估。数据采用Stata 14.0软件分析。结果共纳入10篇文献。meta分析显示,GBV-C感染增加NHL的患病风险(RR=2.36,95%CI:1.52~3.66,P=0.0001)。亚组分析显示,北美GBV-C(RR=2.36,95%CI:1.51~3.68,P<0.001)、欧洲GBV-C(RR=2.57,95%CI:1.41~4.68,P=0.09)与NHL有关;匹配GBV-C与NHL有关(RR=2.18,95%CI:1.23~3.83,P<0.001);B细胞NHL的GBV-C与NHL有关(RR=2.12,95%CI:1.28~3.51,P<0.001)。meta分析结果提示GBV-C感染与滤泡性B细胞NHL(RR=2.06,95%CI:1.58~2.67,P<0.001)、弥漫性B细胞NHL(RR=1.54,95%CI:1.16~2.03,P=0.047)有关。GBV-C感染与HL无关(RR=1.43,95%CI:0.88~2.33,P=0.15)。结论GBV-C感染与NHL密切相关,与HL无关,建议临床工作中重点关注。

Objective To investigate the relationship between human GB virus type C(GBV-C)virus infection and non-Hodgkin lymphoma(NHL)and Hodgkin lymphoma(HL).Methods PubMed,Web of Science,Embase,CNKI,Wanfang database were searched for literatures on the relationship between GBV-C virus infection and NHL and HL.The search time was from January 1990 to July 2021.Two researchers independently screened the literature,extracted data and evaluated the literature.Data was analyzed by using Stata 14.0 software.Results Ten studies were included.Meta analysis showed that GBV-C infection increased the risk of NHL(RR=2.36,95%CI:1.52-3.66,P=0.0001).Subgroup analysis showed that GBV-C in North America(RR=2.36,95%CI:1.51-3.68,P<0.001)and GBV-C in Europe(RR=2.57,95%CI:1.41-4.68,P=0.009)were associated with NHL.Matched GBV-C was associated with NHL(RR=2.18,95%CI:1.23-3.83,P<0.001).GBV-C of NHL in B cells was related to NHL(RR=2.12,95%CI:1.28-3.51,P<0.001).Meta analysis showed that GBV-C infection was related to follicular B-cell NHL(RR=2.06,95%CI:1.58-2.67,P<0.001)and diffuse B-cell NHL(RR=1.54,95%CI:1.16-2.03,P=0.047).GBV-C infection was not associated with HL(RR=1.43,95%CI:0.88-2.33,P=0.15).Conclusion GBV-C infection is closely related to NHL and has nothing to do with HL,so it is suggested to focus on it in clinical work.