具有甲基丙烯酸甲酯-45S5生物活性玻璃复合涂层的镁在模拟体液中的生物降解行为

Biodegradation behavior of polymethyl methacrylate−bioactive glass 45S5 composite coated magnesium in simulated body fluid

研究甲基丙烯酸甲酯(PMMA)和甲基丙烯酸甲酯-生物活性玻璃(BG)复合材料对镁生物降解行为的影响。通过电泳沉积和浸涂技术,利用含有不同比例两种涂层材料的悬浮液制备复合涂层。用SEM、EDS、FTIR和水接触角测量对涂层进行表征。通过线偏振、阻抗谱和模拟体液浸泡实验研究镁的生物降解行为。电镜结果表明,复合涂层致密且均匀。水接触角测量显示,与没有复合涂层的镁相比,具有复合涂层的镁接触角增加44°。复合涂层在模拟体液中浸泡336 h后其表面被类骨羟基磷灰石层覆盖,表明涂层具有良好的体外生物活性。电化学测试结果证实,与未涂覆复合材料涂层的镁相比,涂覆了由45 g/LPMMA和3.5 g/L45S5 BG组成的悬浮液所制复合涂层的镁,其生物降解率显著降低了96.9%。因此,具有复合涂层的镁可作为一种有前景的生物降解植入材料。

The biodegradation behavior of Mg,coated by polymethyl methacrylate as well as polymethyl methacrylate(PMMA)−bioactive glass(BG)composite was investigated.Electrophoretic deposition and dip coating techniques were adopted to prepare composite coating using a suspension of different percentages of the above two chemical materials.The deposited coatings were characterized using SEM,EDS,FTIR,and water contact angle measurements.Biodegradation behavior study of the coated Mg was performed using linear polarization,impedance spectroscopy,and immersion tests in simulated body fluid.The compact and homogeneous composite coating was developed as evidenced by electron microscopy results.The water contact angle measurement showed a 44°increase in the contact angle of the composite coated Mg compared to the uncoated one.The composite coating was covered by a bone-like hydroxyapatite layer after 336 h,indicating that the coating has an excellent in vitro bioactivity.The electrochemical testing results confirmed a significant reduction,96.9%,in the biodegradation rate of Mg coated with the composite prepared from 45 g/L PMMA+3.5 g/L 45S5 GB suspension compared to that of the uncoated one.Therefore,the composite coated Mg can be proposed as a promising material for biodegradable implant application.