脑电图功率谱比值和神经心理测验在主观认知下降诊断中的意义

The meaning of electroencephalogram power spectrum ratio and neuropsychological test in the diagnosis of subjective cognitive decline

目的探讨EEG功率谱比值和神经心理测验在主观认知下降(SCD)诊断中的价值。方法选取2019年11月至2021年1月在我院门诊就诊的SCD患者60例,以及年龄、性别等相匹配的健康对照者30名。分别对两组进行神经心理学测验,对不同脑区的EEG功率谱比值进行比较,分析两组的差异并探讨二者的相关性。结果SCD组即刻记忆、延迟回忆、倒背的评分明显低于健康对照组,差异有统计学意义(均P<0.05)。SCD组额区、颞区的EEG功率谱比值明显高于健康对照组,差异有统计学意义(均P<0.05)。Spearman相关分析显示,SCD组颞区的EEG功率谱比值与延迟回忆中度负相关(r=-0.628,P<0.05)。结论颞区的EEG功率谱比值、延迟回忆测验对早期诊断SCD有一定的临床意义。

Objective To explore the value of EEG power spectrum ratio and neuropsychological test in the diagnosis of subjective cognitive decline(SCD).Methods Sixty patients with SCD and 30 healthy controls with matched age and gender were selected from the outpatient department of our hospital from November 2019 to January 2021.Neuropsychological tests were conducted on the two groups,and the EEG power spectrum ratios in different brain regions were compared.The differences and correlations between the two groups were analyzed.Results The scores of immediate memory,delayed recall and reverse memorization in SCD group were significantly lower than those in healthy control group,and the differences were statistically significant(all P<0.05).The ratio of EEG power spectrum in frontal region and temporal region in SCD group were significantly higher than those in healthy control group,and the differences were statistically significant(all P<0.05).Spearman correlation analysis showed a moderate negative correlation between EEG power spectrum ratio and delayed recall in the temporal region of SCD group(r=-0.628,P<0.05).Conclusion Temporal EEG power spectrum ratio and delayed recall test have certain clinical significance for early diagnosis of SCD.