高毒力肺炎克雷伯菌的研究进展

Research progress of hypervirulent Klebsiella pneumonia

高毒力肺炎克雷伯菌(hvKP)具有较高毒力及高黏液性,易造成健康宿主感染,以肝脓肿最为常见,并引发多部位侵袭性感染及血流感染。目前耐药hvKP相关菌株,尤其是耐碳青霉烯类高毒力肺炎克雷伯菌(CR-hvKP)的出现,给临床诊疗带来更大的挑战。本文从hvKP的流行现状、毒力因子、耐药机制及其感染治疗等方面进行综述。

Hypervirulent Klebsiella pneumoniae(hvKP)is highly virulent and mucinous,and often causes infection in healthy hosts.Liver abscess is the most common infection,which can easily lead to multi-site invasive infection and bloodstream infection.At present,the emergence of drug-resistant hvKP-related strains,especially carbapenem-resistant hypervirulent Klebsiella pneumoniae(CR-hvKP),has brought greater challenges to clinical diagnosis and treatment.In this paper,the epidemic status,virulence factors,drug resistance mechanism and infection treatment of hvKP are reviewed.