长链非编码RNA在结直肠癌中的诊断价值和作用机制

Diagnostic value and mechanism of action of Long non-coding RNA in colorectal cancer

结直肠癌(CRC)是最常见的恶性肿瘤之一,尽管目前CRC的诊断有了长足的进步,但多数病人确诊时已处于晚期,并伴有肿瘤浸润和远处转移,导致预后不佳。长链非编码RNA(lncRNA)是CRC发生的主要原因之一,lncRNA在CRC中的潜在作用机制有待进一步探索。lncRNA在CRC中发挥作用主要与细胞凋亡与逃逸、血管生成、细胞周期、上皮-间充质转化(EMT)、DNA损伤修复以及表观遗传密切相关。我们对lncRNA在CRC中的诊断价值、lncRNA在CRC细胞凋亡与逃逸、血管生成、细胞周期、EMT、DNA损伤修复以及表观遗传中的作用、lncRNA在CRC中的应用价值进行综述。

Colorectal cancer(CRC)is one of the most common malignant tumors.Although the diagnosis of CRC has made great progress,most patients are in advanced stage when diagnosed,accompanied by tumor infiltration and distant metastasis,resulting in poor prognosis.Long non-coding RNA(lncRNA)is one of the main causes of CRC,but the potential mechanism of lncRNA in CRC remains to be further explored.The role of lncRNA in CRC is closely related to the following biological processes,such as apoptosis and escape,angiogenesis,cell cycle,epithelial mesenchymal transition(EMT),DNA damage repair and epigenetics.In this paper,we systematically described the diagnostic value of lncRNA in CRC,then described the role of lncRNA in CRC cell apoptosis and escape,angiogenesis,cell cycle,EMT,DNA damage repair and epigenetics,and finally described the application value and prospect of lncRNA in CRC.