脑小静脉与脑结构变化相关研究进展

Progress on the correlation between cerebral venules and brain structural abnormalities

随着病理学和神经影像学技术的不断进步,应用特殊染色技术结合SWI等影像学技术识别并评估脑小静脉结构、数量等特征,可观察到脑小静脉数目减少、连续性破坏或走行迂曲等异常与脑白质高信号、腔隙、灰质萎缩等结构改变相关,提示广泛性脑白质结构破坏及神经系统变性参与脑小静脉系统疾病的致病过程。本研究结合脑小静脉系统解剖结构及检测方法,进一步认识和探索脑小静脉系统疾病致病机制。

With the development of pathology and neuroimaging, special staining techniques and imaging techniques have been used to identify and evaluate the characteristics of cerebral venules, and found that the decrease of cerebral venules, disruption of continuity and tortuousness, are correlated with the structural changes of white matter hyperintensity(WMH) and gray matter atrophy, suggesting that both white matter damage and the neurodegeneration processes are involved in the pathogenesis of cerebral venule system disease. This review combined the anatomical structure and detection methods of cerebral venules system to further understand and explore the pathogenesis of cerebral venules system diseases.