非IgE介导食物过敏的免疫机制和潜在生物标志物

The immune mechanism and potential biomarkers of non-IgE-mediated food allergy

非IgE介导食物过敏免疫机制复杂, 缺乏具有特异性的实验室指标, 诊断和治疗方式单一, 常出现疾病误诊和诊断延迟, 因此迫切需要深入了解其发病机制, 寻找特异性生物标志物和新的治疗靶点。现从特异性免疫和非特异性免疫两方面总结目前关于非IgE介导食物过敏免疫机制的研究成果, 探讨能够辅助疾病诊断和病情评估的潜在生物标志物, 并为该类过敏性疾病的治疗提供新的思路。

The immune mechanism of non-IgE-mediated food allergy is quite complex.Due to the lack of specific laboratory indicators and limited diagnosis and treatment methods,non-IgE-mediated food allergy is usually misdiagnosed.Therefore,it is urgent to clarify the pathogenesis of the disease and search for specific biomarkers and novel therapeutic targets.This review aims to summarize current research results on the immune mechanism of non-IgE-mediated food allergy from two aspects,including the specific immunity and innate immunity,and to explore the potential diagnostic markers.The results may provide novel ideas for effective therapeutic strategies of non-IgE-mediated food allergy.