同型半胱氨酸、C反应蛋白及心肌标志物与冠心病早期诊断的相关研究

Correlation of Homocysteine,C-reactive Protein and Myocardial Markers with Early Diagnosis of Coronary Heart Disease

目的探讨血液指标同型半胱氨酸(HCY)、C反应蛋白(CRP)以及心肌标志物与冠心病早期诊断的相关性。方法选取2020年8月-2021年3月在上海市浦东新区公利医院诊断的102例冠心病患者作为观察组,将其再分为心绞痛(AP)组88例和心肌梗死(AMI)组14例。另选取同时期就诊我院的健康体检者60例作为对照组。比较观察组初诊时与对照组血液中HCY、CRP以及心肌标志物的浓度水平,探究其与冠心病诊断的相关性。结果观察组HCY、CRP、TNI、CK-MB、MYO的血液浓度水平均高于对照组,差异有统计学意义(P<0.05);AMI组TNI、CK-MB、MYO的血液浓度水平均高于AP组,差异有统计学意义(P<0.05)。结论血浆HCY、CRP、TNI、CK-MB、MYO水平与早期冠心病有密切关系,并且有助于判断冠心病的病变程度。

Objective To investigate the correlation between blood homocysteine(HCY),C-reactive protein(CRP),myocardial markers and early diagnosis of coronary heart disease.Methods A total of 102 patients with coronary heart disease diagnosed in Shanghai Pudong New Area Gongli Hospital,from August 2020 to March 2021 were selected as the observation group.They were divided into angina pectoris(AP)group(88 cases)and myocardial infarction(AMI)group(14 cases).In addition,60 healthy people who visited our hospital in the same period were selected as the control group.The concentrations of HCY,CRP and myocardial markers in the blood of the observation group and the control group at the first diagnosis were compared to explore their correlation with the diagnosis of coronary heart disease.Results The blood concentration levels of HCY,CRP,TNI,CK-MB and MYO in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The blood concentrations of TNI,CK-MB and MYO in AMI group were higher than those in AP group,and the difference was statistically significant(P<0.05).Conclusion Plasma HCY,CRP,TNI,CK-MB,MYO levels are closely related to early coronary heart disease,and help to determine the severity of coronary heart disease.