基于肠道菌群数量和5-羟色胺表达分析围绝经期女性抑郁状态与肠道紊乱的相关性及心理康复疗效

To analyze the correlation between depression and intestinal disorder in perimenopausal women and the effect of psychological rehabilitation based on intestinal flora number and 5-hydroxytryptamine expression

目的 基于肠道菌群数量和5-羟色胺(5-HT)表达探究围绝经期女性抑郁状态与肠道紊乱的相关性及心理康复的临床疗效。方法 选取2021年1-6月在天津市第五中心医院接受治疗的51例围绝经期抑郁女性患者为病例组,另选取同期在该院进行健康体检的43例健康女性受检者为对照组。观察两组研究对象肠道菌群检出情况和血清5-HT表达水平,比较病例组患者心理康复干预前后血清5-HT表达、抑郁量表(SDS)评分及腹胀程度评分的差异;Pearson相关系数分析血清5-HT表达、腹胀程度评分与SDS评分的相关性。结果 病例组患者双歧杆菌、肠杆菌值均明显高于对照组,差异均有统计学意义(均P<0.05)。干预后,病例组患者血清5-HT表达水平高于干预前,SDS评分、腹胀程度评分均低于干预前,差异均有统计学意义(均P<0.05)。Pearson相关系数分析结果显示,血清5-HT与SDS评分呈负相关关系(r=-0.722,P<0.05),腹胀程度评分与SDS评分呈正相关关系(r=0.730,P<0.05)。结论 围绝经期抑郁女性患者益生菌群数量与正常女性相比具有明显差异,5-HT表达水平低于正常女性,但接受心理康复干预后,其5-HT表达水平和肠道紊乱症状均有所改善,且患者抑郁状态与肠道紊乱状况、5-HT表达具有相关性,后续临床可通过检测围绝经期女性肠道情况、5-HT表达水平评估患者心理状态,并针对性地制定有效诊疗方案来提高治疗效果。

Objective To explore the correlation between depression and intestinal disorder in perimenopausal women and the clinical effect of psychological rehabilitation based on the number of intestinal flora and the expression of 5-hydroxytryptamine(5-HT).Methods 51 female patients with perimenopausal depression treated in Tianjin Fifth Central Hospital from January to June 2021 were selected as the case group, and 43 healthy female subjects who underwent physical examination in the hospital in the same period were selected as the control group.The detection of intestinal flora and the expression level of serum 5-HT in the two groups were observed, and the differences of serum 5-HT expression, depression scale(SDS) score and abdominal distension score before and after psychological rehabilitation intervention in the case group were compared;Pearson correlation coefficient was used to analyze the correlation between serum 5-HT expression, abdominal distension score and SDS score.Results The values of Bifidobacterium and Enterobacter in the case group were significantly higher than those in the control group(all P<0.05).After the intervention, the expression level of serum 5-HT in the case group was higher than that before the intervention, and the SDS score and abdominal distension score were lower than those before the intervention(all P<0.05).Pearson correlation coefficient analysis showed that there was a negative correlation between serum 5-HT and SDS score(r=-0.722, P<0.05), and a positive correlation between abdominal distension score and SDS score(r=0.730, P<0.05).Conclusion The number of probiotics in perimenopausal depressed women is significantly different from that in normal women.The expression level of 5-HT is lower than that in normal women.However, after psychological rehabilitation intervention, the expression level of 5-HT and intestinal disorder symptoms are improved, and the depression state of patients is correlated with intestinal disorder and 5-HT expression.In subsequent clinical practice, the psychological state of patients can be evaluated by detecting the intestinal condition and 5-HT expression level of perimenopausal women, and formulate effective diagnosis and treatment plans to improve the treatment effect.