双歧杆菌四联活菌对高龄患者发生抗生素相关性腹泻的预防价值研究

Study on the preventive value of bifidobacterium tetragenus viable bacteria on the occurrence of antibiotic-associated diarrhea in elderly patients

目的探讨双歧杆菌四联活菌对高龄患者发生抗生素相关性腹泻的预防价值。方法选取2020年3月~2021年6月住院治疗且有感染性疾病发生的高龄患者68例为研究对象,按随机数表法将患者分组,两组患者均结合病情应用抗生素治疗,观察组联用双歧杆菌四联活菌治疗。统计两组患者抗生素应用7 d内的AAD发生率,检测两组患者的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平。检测两组患者的肠道菌群数量和肠屏障功能[包括细菌内毒素(BT)、二胺氧化酶(DAO)、D-乳酸(D-LC)]。结果观察组AAD发生率为2.94%,对照组为20.59%,两组差异有统计学意义(χ^(2)=5.108,P<0.05)。用药前,两组免疫功能IgA、IgM、IgG水平,肠道菌群双歧杆菌、肠杆菌、乳杆菌水平,肠屏障功能BT、DAO、D-LC比较,差异均无统计学意义(P>0.05);用药后,观察组的免疫功能水平高于对照组,肠道菌群数量高于对照组,肠屏障功能受损程度轻于对照组,差异均有统计学意义(P<0.05)。结论高龄患者应用抗生素治疗期间,联合服用双歧杆菌四联活菌,可预防抗生素相关性腹泻,改善人体免疫功能、肠道菌群,减轻肠屏障功能受损情况。

Objective To explore the preventive value of bifidobacteria quadruple viable bacteria on the occurrence of antibiotic-related diarrhea in elderly patients.Methods A total of 68 elderly patients who were hospitalized in our hospital from March 2020 to June 2021 and had infectious diseases were selected as the research objects.The patients were grouped according to the random number table method.Both groups of patients were treated with antibiotics in combination with their condition.The observation group was treated with Bifidobacterium quadruple live bacteria.The incidence of AAD within 7 days of antibiotic application in the two groups of patients was counted,and the levels of immunoglobulin A,immunoglobulin M,and immunoglobulin G in the two groups were detected.The number of intestinal flora and intestinal barrier function[including bacterial endotoxin,diamine oxidase,D-lactic acid]of the two groups of patients were tested.Results The incidence of AAD was 2.94%in the observation group and 20.59%in the control group.The difference between the two groups was statistically significant(χ^(2)=5.108,P<0.05).Before medication,the two groups of immune function IgA,IgM,IgG levels,intestinal flora Bifidobacterium,Enterobacter,Lactobacillus level,intestinal barrier function BT,DAO,D-LC,the difference was not statistically significant(P>0.05);After treatment,the immune function level of the observation group was higher than that of the control group,the number of intestinal flora was higher than that of the control group,and the degree of intestinal barrier function impairment was lighter than that of the control group.The differences were statistically significant(P<0.05).Conclusion During the treatment of elderly patients with antibiotics,the combined use of Bifidobacterium quadruple viable bacteria can prevent antibiotic-related diarrhea,improve human immune function,intestinal flora,and reduce the impairment of intestinal barrier function.