N^(6)-甲基腺苷修饰在心肌再生中作用研究进展

Role of N^(6)-methyladenosine in cardiac regeneration

N^(6)-甲基腺苷(N^(6)-methyladenosine,m^(6)A)修饰是真核生物常见的mRNA转录后修饰方式,受甲基化酶和去甲基化酶动态调控,与胚胎干细胞自我更新和分化、器官发育、组织细胞再生等密切相关。心脏病与心肌细胞损伤或功能障碍有关,心肌损伤后形成心肌纤维化瘢痕,导致心律失常、心力衰竭甚至死亡。临床治疗可改善心脏病患者的心功能,但无法使已丢失的心肌细胞再生。m^(6)A修饰作为一种常见的表观遗传调控方式,在心肌再生中发挥重要作用。本文就m^(6)A修饰在心肌再生中作用的研究进展作一综述。

N^(6)-methyladenosine modification is a common post-transcriptional modification of eukaryotic mRNA,which is dynamically regulated by methylase and demethylase,and is closely corelated with the self-renewal and differentiation of embryonic stem cells,organ development,and tissue cell regeneration.Cardiac disease is associated with the injury or dysfunction of cardiomyocytes,and the formation of myocardial fibrotic scars after damage ultimately leads to arrhythmia,heart failure and death.Current treatments can improve the heart function but cannot regenerate the lost cardiomyocytes.N^(6)-methyladenosine modification plays an important role in cardiac regeneration as a common epigenetic regulation method.This paper reviews the research progress of the role of N^(6)-methyladenosine modification in myocardial regeneration.