氨磺必利与利培酮治疗精神分裂症的有效性及不良反应

Efficacy and adverse reactions of amisulpride and risperidone in the treatment of schizophrenia

目的探讨精神分裂症临床治疗中应用氨磺必利与利培酮的疗效及安全性。方法遴选2019年5月~2020年5月期间的70例精神分裂症患者,根据治疗方式差异性分组,对照组35例,采用利培酮治疗;观察组35例,采用氨磺必利治疗。对临床总有效率,精神状态,生活质量,不良反应率,糖脂代谢及催乳素等指标对比分析。结果治疗前,2组PANSS评分对比无显著差异(P>0.05);治疗后,与对照组相比,观察组PANSS评分更低,生活质量评分更高,临床总有效率更高(P<0.05)。治疗前,2组催乳素,糖脂代谢指标水平组间对比均差异不显著(P>0.05);治疗后,2组较治疗前胰岛素抵抗指数(IR),甘油三脂(TG),催乳素(RBI)指标值均升高,且观察组较对照组RBI水平相对低,具有统计学差异(P<0.05)。治疗后组间体质指数(BMI),IR,TG,总胆固醇(TC)指标水平对比无统计学差异(P>0.05);2组不良反应率对比无统计学差异(P>0.05),且经对症处理均消失。结论应用氨磺必利治疗精神分裂症相比利培酮,临床疗效相近,可改善患者精神症状,有效提高生活质量,但用药安全性有保证。

Objective To explore the difference and safety of amisulpride and risperidone in the clinical treatment of schizophrenia.Methods A total of 70 patients with schizophrenia from May 2019 to May 2020 were selected and grouped according to the differences in treatment methods.35 cases were treated with risperidone(denoted as the control group),and 35 cases were treated with amisulpride(denoted as the observation group),the clinical total effective rate,mental state,quality of life,adverse reaction rate,glucose and lipid metabolism and prolactin and other indicators were compared and analyzed.Results Before treatment,there was no significant difference in PANSS score between the two groups(P>0.05).After treatment,the PANSS score of the observation group was lower,the quality of life score of the observation group was significantly higher,and the clinical total effective rate was higher than that of the control group(P<0.05).Before treatment,there was no significant difference in prolactin,glucose and lipid metabolism indexes between the two groups(P>0.05).After treatment,the IR,TG and RBI indexes of the two groups were higher than before treatment,and the RBI level of the observation group was lower than that of the control group(P<0.05).There was no significant difference in BMI,IR,TG and TC indexes between the two groups after treatment(P>0.05);There was no significant difference in the adverse reaction rate between the two groups(P>0.05),and it disappeared after symptomatic treatment.Conclusion Compared with risperidone,amisulpride has more significant clinical effect in the treatment of schizophrenia,which can improve the mental symptoms of patients,effectively improve the quality of life,ensure the safety of medication,and improve the prognosis of the disease.