帕罗西汀对围绝经期抑郁患者的效果及其对性激素,神经递质水平的影响

The effect of paroxetine in the treatment of patients with perimenopausal depression and its influence on their serum sex hormone and neurotransmitter levels

目的探究围绝经期抑郁障碍患者应用帕罗西汀的效果及对血清神经递质,性激素水平的影响机制。方法2019年7月~2021年7月期间89例围绝经期抑郁障碍患者作为研究对象,对照组44例给予雌激素替代疗法联合心理治疗,观察组45例增加帕罗西汀治疗,对比两组患者抑郁状况,血清性激素水平,神经递质水平,不良反应。结果治疗12周后,观察组患者雌二醇水平高于对照组(P<0.05),促黄体生成素及促卵泡生成激素水平低于对照组(P<0.05);观察组Kupperman评分及汉密尔顿抑郁量表评分均低于对照组(P<0.05);观察组脑源性神经营养因子,5-羟色胺及去甲肾上腺素水平均高于对照组(P<0.05);观察组发生嗜睡,胃肠道不良反应,头痛例数与对照组比较差异无统计学差异(P>0.05)。结论帕罗西汀治疗围绝经期抑郁障碍患者的效果显著,可明显提高患者神经递质水平,调节血清性激素水平,改善患者抑郁状态。

Objective To explore the effect of paroxetine in patients with perimenopausal depression and the mechanism of its effect on serum neurotransmitter and sex hormone levels.Methods From July 2019 to July 2021,89 patients with perimenopausal depressive disorder were used as the research object.The control group was given estrogen replacement therapy combined with psychotherapy for 44 patients,and the observation group was treated with paroxetine for 45 patients,and the depressive level,serum sex hormone levels,neurotransmitter levels and adverse reactions between two groups were compared.Results After 12 weeks of treatment,the level of estradiol in the observation group was higher than that in the control group(P<0.05),and the levels of luteinizing hormone and folliclestimulating hormone were lower than those in the control group(P<0.05).The observation group's Kupperman score and the scores of Hamilton Depression Scale were lower than those of the control group(P<0.05).The brain-derived neurotrophic factor,serotonin and norepinephrine levels in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the number of drowsiness,gastrointestinal adverse reactions,and headaches between two groups(P>0.05).Conclusion Paroxetine is effective in treating patients with perimenopausal depressive disorder.It can significantly increase the level of neurotransmitters,regulate the level of serum sex hormones,and improve the depressive state of patients.