PI3K/AKT/mTOR信号通路参与自身免疫性疾病发病的研究进展

Research progress of PI3K/AKT/mTOR signaling pathway in pathogenesis of autoimmune diseases

自身免疫性疾病(autoimmune disease,AD)是机体因自身抗原免疫耐受障碍而对自身抗原产生免疫反应,从而引起机体组织损伤的一类疾病。近年研究发现,磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白(phosphatidylin ositol 3-kinase/protein kinase B/mechanistic target of rapamycin kinase,PI3K/AKT/mTOR)信号通路与AD发病密切相关,其主要参与免疫细胞增殖分化、炎性细胞因子分泌、自噬及氧化应激等过程。本文重点概述PI3K/AKT/mTOR信号通路参与AD发病机理的研究进展。

Autoimmune diseases(ADs)are a kind of diseases caused by the disorder of immune tolerance and the immune response to autoimmune antigens.Recent studies have found that there are close relationship between the phosphatidylinositol-3-kinase/protein kinase B/target of rapamycin(PI3K/AKT/mTOR)signaling pathway and AD,mainly involved in immune cell proliferation and differentiation,inflammatory cytokine secretion,autophagy levels,and abnormal oxidative stress.This review focuses on the research progress of PI3K/AKT/mTOR signaling pathway in the pathogenesis of AD.