miRNA调节自噬在眼科疾病中的应用

Role of microRNA-regulated autophagy in ophthalmic diseases

细胞自噬是一种通过溶酶体途径降解异常的细胞质蛋白和受损的细胞器的分解代谢过程,其过程失调已被发现与多种眼科疾病发生有关。微小RNA(miRNA)是一类非编码的内源性小分子RNA,其通过识别目的基因3’末端非翻译区来下调自噬相关基因及其调节因子表达。研究表明,miRNA表达异常可导致自噬失调,使miRNA成为治疗自噬失调相关的眼科疾病的潜在靶点。本文将对眼科疾病中有关miRNA参与细胞自噬调控的最新研究进展进行综述。

Autophagy is a catabolic process to degrade abnormal cytoplasmic proteins and damaged organelles through the lysosomal pathway,and its dysregulation is associated with many ophthalmic diseases.MicroRNA(miRNA)is a class of endogenous small non-coding RNA molecules,which down-regulates the expression of autophagy-related genes and their regulatory factors by recognizing the 3’-terminal untranslated region of target genes.Studies have shown that abnormal miRNA expression can lead to autophagy disorders;thus,miRNA is a potential target for the treatment of ophthalmic diseases related to autophagy disorders.This paper reviews the latest research on the role of autophagy regulated by miRNA in ophthalmic diseases.