益气活血法治疗多重耐药菌感染脓毒症的临床研究

Clinical Study on Sepsis of Multiple Resistant Bacteria

目的:探讨中医益气活血法对多重耐药菌(MDROs)感染脓毒症患者的治疗价值与预后效果。方法:选择2020年1月至2021年1月本院收治的80例MDROs感染脓毒症患者开展研究,采取用前瞻性随机对照研究的方式把这80例患者随机分成常规治疗组和中药干预组,每组有病患40例,所有患者均按照指南常规西医综合治疗,中药干预组在此基础上加用益气活血散冲服,7天为1疗程,治疗后对比两组症状改善情况。结果:治疗后,中医干预组的中医症状积分、APACHE-Ⅱ评分均显著低于常规治疗组(P<0.05);中医干预组的炎症反应指标、免疫指标等改善程度均显著优于常规治疗组(P<0.05);中医干预组的住院时间、ICU住院时间、住院费用、28天病死率等指标均优于常规治疗组(P<0.05)。结论:对于MDROs感染脓毒症患者,实施常规西医治疗联合益气活血法治疗,能够显著改善该病的临床指标及与预后情况,减少患者的器官功能损害,降低病死率,能够为中医药治疗此类疾病提供循证医学依据,值得推荐。

Objective:To explore the therapeutic value and prognostic effect of TCM supplementing qi and activating blood method on sepsis patients infected with multidrug-resistant bacteria(MDROs).Methods:80 patients with MDROs-infected sepsis admitted to our hospital from January 2020 to January2021 were selected for research,and the 80 patients were randomly divided into a conventional treatment group and a traditional Chinese medicine intervention group by means of a prospective randomized controlled study.There were 40 patients in the group.All patients were treated with conventional western medicine in accordance with the guidelines.On the basis of the Chinese medicine intervention group,Yiqi Huoxue powder was added,and 7 days was a course of treatment.After treatment,the symptoms of the two groups were compared.Results:After treatment,the TCM symptom score and APACHE-Ⅱscore in the TCM intervention group were significantly lower than those in the conventional treatment group(P<0.05);the improvement degrees of the inflammatory response indexes and immune indexes in the TCM intervention group were significantly better than those in the conventional treatment group(P<0.05);the TCM intervention group was better than the conventional treatment group in terms of hospitalization time,ICU stay,hospitalization expenses,and 28-day mortality rate(P<0.05).Conclusion:For MDROs-infected sepsis patients,conventional western medicine treatment combined with Qi-invigorating and blood activating therapy can significantly improve the clinical indicators and prognosis of the disease,reduce the patient's organ function damage,and reduce the mortality rate,which can be used for traditional Chinese medicine treatment.Such diseases provide evidence-based medicine and are worthy of recommendation.